Effect of Different Levels of Copper and Molybdenum Supplements on Serum Lipid Profiles and Antioxidant Status in Cashmere Goats
Effect of Different Levels of Copper and Molybdenum Supplements on Serum Lipid Profiles and Antioxidant Status in Cashmere Goats
复制标题
不同水平的铜和钼补充剂对绒山羊血清脂质谱和抗氧化状态的影响
DOI：
10.1007/s12011-012-9380-2
复制
发表时间：
2012-03
影响因子：
3.9
通讯作者：
Wang, Run L.
中科院分区：
文献类型：
--
作者：
Zhang, Wei;Zhang, Yu;Zhang, Shi W.;Song, Xian Z.;Jia, Zhi H.;Wang, Run L.
本试验旨在研究不同水平的铜(铜：0、19、38 mg/kg)和钼(钼：0、5 mg/kg)对绒山羊生长发育过程中血脂和抗氧化状态的影响。36只辽宁绒山羊(约1.5岁，体重27.53 ± 1.38 kg)采用完全随机设计，采用2 × 3析因设计，分成6个处理。将山羊单独圈养，饲喂含铜4.72 mg/kg、钼0.16 mg/kg、S 0.21 %的中国野生黑麦和紫花苜蓿干草日粮84天。于第84天采集血样。甘油三酯浓度在不同处理之间没有差异(P>； 0.05)。无论钼水平如何，添加铜均能降低血清总胆固醇和低密度脂蛋白胆固醇浓度(P<； 0.05)，升高血清高密度脂蛋白胆固醇浓度(P<； 0.05)，但各补铜组间差异不显著(P>； 0.05)。补铜可提高血清铜蓝蛋白、铜锌超氧化物歧化酶和谷胱甘肽过氧化物酶活性(P<； )，降低丙二醛含量(P<； 0.05)。补钼还能提高血清GSH-Px活性(P<； )。铜钼交互作用对血清CP(P= 0.094)、GSH-Px(P= 0.057)和GSH-Px(P= 0.062)活性有交互作用的趋势，在不加钼的条件下，以19 mg/kg组最高，而38 mg/kg组和5 mg Mo/kg组的血清CP和GSH-Px活性最高。添加铜、钼或它们的交互作用对血清谷草转氨酶、谷丙转氨酶和乳酸脱氢酶的活性以及血糖和总蛋白的浓度没有影响(P>； 0.05)。综上所述，为了改变绒山羊的脂肪代谢，获得最佳的抗氧化活性，建议在不添加钼的基础日粮中添加19 mg/kg的铜(日粮总铜水平为23.72 mg/kg)，而在生绒期的基础日粮中添加5 mg/kg的钼(总水平分别为42.72 mg/kg、5.16 mg/kg和0.21 %S)时，应添加38 mg/kg的铜。
An experiment was conducted to investigate on the effects of different levels of copper (Cu: 0, 19, and 38 mg/kg) and molybdenum (Mo: 0 and 5 mg/kg) supplements and the interaction of these two factors on serum lipid profiles and antioxidant status in cashmere goats during the cashmere fiber growing period. Thirty-six Liaoning cashmere goats (approximately 1.5 years of age; 27.53 ± 1.38 kg of body weight) were assigned to one of six treatments in a completely randomized design involving a 2 × 3 factorial arrangement. Goats were housed in individual pens and fed with Chinese wild rye- and alfalfa hay-based diet containing 4.72 mg Cu/kg, 0.16 mg Mo/kg, and 0.21 % S for 84 days. Blood samples were collected on day 84. The triglyceride concentration did not differ among treatments (P> 0.05). Supplemental Cu, regardless of Mo level, decreased (P< 0.05) the concentrations of serum total cholesterol and low density lipoprotein cholesterol, and increased (P< 0.05) the concentration of serum high density lipoprotein cholesterol, but there were no differences (P> 0.05) in these values between Cu-supplemented groups. Supplemental Cu increased (P< 0.05) the activities of serum ceruloplasmin (Cp), Cu–zinc superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px), and decreased (P< 0.05) the malondialdehyde content. The serum GSH-Px activity was also increased (P< 0.05) by Mo supplementation. There was a tendency of the interaction effects of Cu and Mo on the activities of Cp (P= 0.094), SOD (P= 0.057), and GSH-Px (P= 0.062), and goats fed with 19 mg Cu/kg in the absence of Mo tended to show the highest serum SOD activity, while goats fed with 38 mg Cu/kg with 5 mg Mo/kg tended to show the highest values of serum Cp and GSH-Px. Addition of Cu, Mo, or their interaction had no influence (P> 0.05) on the activities of serum glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, and lactate dehydrogenase, and the concentrations of serum glucose and total protein. In conclusion, addition of 19 mg Cu/kg in the absence of Mo (the total dietary Cu level of 23.72 mg/kg) was recommended for altering the fat metabolism and obtaining the optimal antioxidant activity of cashmere goats, while 38 mg Cu/kg should be supplemented when 5 mg Mo/kg was added in the basal diet (the total dietary level of 42.72 mg Cu/kg, 5.16 mg Mo/kg, and 0.21 % S) during the cashmere growing period.
登录
查看更多内容
DOI：
10.1093/jaoac/60.6.1355
发表时间：
1977-11
期刊：
Journal - Association of Official Analytical Chemists
影响因子：
--
作者：
W. Horwitz
通讯作者：
W. Horwitz
影响因子：
3.2
作者：
Chandan Datta;M. Mondal;P. Biswas
通讯作者：
Chandan Datta;M. Mondal;P. Biswas
DOI：
10.1007/0-306-47466-2_235
发表时间：
2002
期刊：
--
影响因子：
--
作者：
T. Engle;J. Spears;C. Wright;T. A. Armstrong
通讯作者：
T. Engle;J. Spears;C. Wright;T. A. Armstrong
影响因子：
3.5
作者：
K. Jenkins;J.K.G. Kramer
通讯作者：
K. Jenkins;J.K.G. Kramer
DOI：
10.1079/9780851995953.0285
发表时间：
2002
期刊：
--
影响因子：
--
作者：
J. Lee;S. Knowles;G. Judson;M. Freer;H. Dove
通讯作者：
J. Lee;S. Knowles;G. Judson;M. Freer;H. Dove