Rethinking schizophrenia in the context of normal neurodevelopment.
Rethinking schizophrenia in the context of normal neurodevelopment.
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DOI：
10.3389/fncel.2013.00060
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发表时间：
2013
影响因子：
5.3
通讯作者：
Shannon Weickert C
中科院分区：
文献类型：
--
作者：
Catts VS;Fung SJ;Long LE;Joshi D;Vercammen A;Allen KM;Fillman SG;Rothmond DA;Sinclair D;Tiwari Y;Tsai SY;Weickert TW;Shannon Weickert C
精神分裂症的大脑与正常大脑有细微的区别，正常和疾病状态之间的测量有明显的重叠。在过去的25年里，精神分裂症越来越多地被认为是一种神经发育障碍。这个参考框架挑战生物学研究人员考虑如何在成人脑组织中发现的病理变化可以通过胎儿，儿童或青少年时期发生的异常发育过程来解释。将精神分裂症神经病理学置于神经发育背景下，需要坚实的、仔细检查的证据来证明人脑正常发育过程中发生的变化，特别是在皮层;然而，关于规范性发育变化的数据往往被选择性地引用。这篇论文的重点是前额叶皮层的发展，并在类似的时间线上绘制了主要的分子、细胞和行为事件。我们首先考虑人类认知能力（如选择性注意力、工作记忆和抑制控制）成熟的时间，强调充分实现成人潜力是一个需要数十年的过程。我们回顾了神经发生、神经元迁移、白色物质变化（髓鞘形成）和突触发育的时间。我们考虑神经递质信号通路的分子变化如何在整个生命过程中改变，以及它们如何伴随细胞和认知变化。最后，我们考虑如何对滥用药物的反应随年龄的变化。我们的结论是，周围的皮质神经元迁移的时间，interneuron成熟，在人类突触退化的概念可能需要修订，包括更强调青春期发生的长期和动态的变化。更新我们目前对出生后神经发育的理解应该有助于研究人员解释灰质变化和脱轨的神经发育过程，这些过程可能是精神病出现的基础。
The schizophrenia brain is differentiated from the normal brain by subtle changes, with significant overlap in measures between normal and disease states. For the past 25 years, schizophrenia has increasingly been considered a neurodevelopmental disorder. This frame of reference challenges biological researchers to consider how pathological changes identified in adult brain tissue can be accounted for by aberrant developmental processes occurring during fetal, childhood, or adolescent periods. To place schizophrenia neuropathology in a neurodevelopmental context requires solid, scrutinized evidence of changes occurring during normal development of the human brain, particularly in the cortex; however, too often data on normative developmental change are selectively referenced. This paper focuses on the development of the prefrontal cortex and charts major molecular, cellular, and behavioral events on a similar time line. We first consider the time at which human cognitive abilities such as selective attention, working memory, and inhibitory control mature, emphasizing that attainment of full adult potential is a process requiring decades. We review the timing of neurogenesis, neuronal migration, white matter changes (myelination), and synapse development. We consider how molecular changes in neurotransmitter signaling pathways are altered throughout life and how they may be concomitant with cellular and cognitive changes. We end with a consideration of how the response to drugs of abuse changes with age. We conclude that the concepts around the timing of cortical neuronal migration, interneuron maturation, and synaptic regression in humans may need revision and include greater emphasis on the protracted and dynamic changes occurring in adolescence. Updating our current understanding of post-natal neurodevelopment should aid researchers in interpreting gray matter changes and derailed neurodevelopmental processes that could underlie emergence of psychosis.
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影响因子：
6.6
作者：
BENES, FM
通讯作者：
BENES, FM
DOI：
10.1016/j.ijdevneu.2010.03.004
发表时间：
2010-08-01
影响因子：
1.8
作者：
Abraham, Hajnalka;Vincze, Andras;Seress, Laszlo
通讯作者：
Seress, Laszlo
DOI：
10.1093/cercor/bhm184
发表时间：
2008-07
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Bayatti N;Moss JA;Sun L;Ambrose P;Ward JF;Lindsay S;Clowry GJ
通讯作者：
Clowry GJ
影响因子：
4.5
作者：
Anderson, SA;Volk, DW;Lewis, DA
通讯作者：
Lewis, DA
影响因子：
2.9
作者：
Bava, Sunita;Thayer, Rachel;Jacobus, Joanna;Ward, Megan;Jernigan, Terry L.;Tapert, Susan F.
通讯作者：
Tapert, Susan F.