Longitudinal characterization of white matter maturation during adolescence.
Longitudinal characterization of white matter maturation during adolescence.
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DOI：
10.1016/j.brainres.2010.02.066
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发表时间：
2010-04-23
期刊：
影响因子：
2.9
通讯作者：
Tapert, Susan F.
中科院分区：
文献类型：
--
作者：
Bava, Sunita;Thayer, Rachel;Jacobus, Joanna;Ward, Megan;Jernigan, Terry L.;Tapert, Susan F.
青春期后期是由相当大的发展过渡，虽然在这一时期的大脑成熟的变化是微妙的，难以定量评估从标准的大脑成像采集。迄今为止，主要是横断面研究的特点是典型的发展变化，在青春期，但这些过程需要进一步的纵向框架内的描述。为了评估典型的白色物质发育的发展轨迹，我们检查了22名健康青少年，在平均年龄17.8岁和16个月后收集了一系列弥散张量图像（DTI）。扩散参数分数各向异性，平均值，径向和轴向扩散率进行全脑体素时间点比较，使用tract为基础的空间统计。在随访时，青少年在弥散特性方面显示出显著变化（≥ 153个连续体素，每个p<0.01），包括双侧上级纵束、上级放射冠、丘脑前放射和内囊后肢。总体而言，与认知表现的相关性表明，行为改善与白色物质的变化相对应。这些纵向DTI结果支持青春期后期白色物质的持续微结构变化，并表明投射和联合纤维持续细化到成年早期。
Late adolescence is comprised of considerable developmental transitions, though brain maturational changes during this period are subtle and difficult to quantitatively evaluate from standard brain imaging acquisitions. To date, primarily cross-sectional studies have characterized typical developmental changes during adolescence, but these processes need further description within a longitudinal framework. To assess the developmental trajectory of typical white matter development, we examined 22 healthy adolescents with serial diffusion tensor images (DTI) collected at a mean age of 17.8 years and 16-months later. Diffusion parameters fractional anisotropy, and mean, radial, and axial diffusivity were subjected to whole-brain voxelwise time point comparisons using tract-based spatial statistics. At follow-up, adolescents showed significant change (≥ 153 contiguous voxels each at p<.01) in diffusion properties, including in bilateral superior longitudinal fasciculi, superior corona radiata, anterior thalamic radiations, and posterior limb of the internal capsule. Overall, correlations with cognitive performances suggested behavioral improvement corresponding with white matter changes. These longitudinal DTI findings support continued microstructural change in white matter during late adolescence, and suggest ongoing refinement of projection and association fibers into early adulthood.
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影响因子：
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DOI：
10.15288/jsa.1998.59.427
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