Exposure to nicotine during gestation interferes with the colonization of fetal bone marrow by hematopoietic stem/progenitor cells.
Exposure to nicotine during gestation interferes with the colonization of fetal bone marrow by hematopoietic stem/progenitor cells.
复制标题
妊娠期间接触尼古丁会干扰造血干细胞/祖细胞在胎儿骨髓中的定植。
DOI：
10.1089/scd.2005.14.81
复制
发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Khaldoyanidi,SophiaK
中科院分区：
文献类型：
--
作者：
Serobyan,Naira;Orlovskaya,Irina;Kozlov,Vladimir;Khaldoyanidi,SophiaK
环境因素，包括香烟烟雾成分，可以穿过胎盘屏障，积聚在羊水和胎儿组织中，因此干扰个体发育的正常过程。尽管香烟烟雾含有许多化合物，但对哺乳动物组织最不利的影响一直与尼古丁有关。本研究的目的是探讨宫内尼古丁暴露对胎儿发育和产后造血的影响。小鼠出生后1个月，宫内暴露于尼古丁可导致迟发型超敏反应(DTH)降低两倍以上，子代空斑形成细胞(PFC)数量减少2.5倍，这与造血组织中成熟淋巴细胞和淋巴祖细胞数量减少有关。孕期接触尼古丁的新生儿骨髓造血祖细胞集落形成单位(CFU)和长期培养启动细胞(LTC-IC)检测结果显示，其骨髓造血祖细胞显著减少，血清中IL-6浓度降低。对来自尼古丁暴露胎儿的胎儿骨髓(E15)的分析表明，造血祖细胞的数量较少，而胎肝中的造血祖细胞数量没有明显变化。我们的数据提供了证据表明，尼古丁通过靶向烟碱型乙酰胆碱受体(NAChR)，干扰了胎儿造血系统的发育。造血干/祖细胞(HSPC)在胎儿骨髓中的劣性定植导致出生后成熟血液和免疫细胞产生的失衡。
Environmental factors, including cigarette smoke components, can cross the placental barrier and accumulate in amniotic fluid and fetal tissue, and, therefore, interfere with the normal course of ontogenesis. Although cigarette smoke contains numerous compounds, the most adverse effects on mammalian tissues have been associated with nicotine. The aim of this study was to investigate the effect of intrauterine exposure to nicotine on hematopoiesis during fetal development and postpartum. Intrauterine exposure of mice to nicotine resulted in a more than two-fold reduction of the delayed- type hypersensitivity (DTH) response and a 2.5-fold decrease in the number of plaque forming cell (PFC) in offspring after 1 month of postnatal life, and correlated with low counts of mature lymphocytes and lymphoid progenitors in hematopoietic tissues. Neonates exposed to nicotine during gestation showed a significant decrease in the number of bone marrow hematopoietic progenitors, as measured by colony-forming unit (CFU) and long-term culture initiating cell (LTC-IC) assays, and decreased concentration of interleukin-6 (IL-6) in their serum. Analysis of the fetal bone marrow (E15) obtained from nicotine-exposed fetuses demonstrated a lower number of hematopoietic progenitors, whereas their number in the fetal liver was not significantly changed. Our data provide evidence that by targeting the nicotinic acetylcholine receptor (nAChR) nicotine interferes with the fetal development of the hematopoietic system. Inferior colonization of the fetal bone marrow by hematopoietic stem/progenitor cells (HSPC) subsequently results in an imbalance of mature blood and immune cell production after birth.
登录
查看更多内容
DOI：
10.1016/0045-6039(78)90012-x
发表时间：
1978-01-01
期刊：
CELL DIFFERENTIATION
影响因子：
--
作者：
MARTIN, C;BEAUPAIN, D;DIETERLENLIEVRE, F
通讯作者：
DIETERLENLIEVRE, F
影响因子：
20.3
作者：
Kim, CH;Broxmeyer, HE
通讯作者：
Broxmeyer, HE
IL-13 诱导未成熟人胎儿 B 细胞的增殖、Ig 同种型转换和 Ig 合成。
影响因子：
4.4
作者：
J. Punnonen;J. D. de Vries
通讯作者：
J. D. de Vries
脐带血巨核细胞祖细胞对IL-3、IL-6和再生障碍犬血清的反应随胎龄而变化
影响因子：
6.5
作者：
V. Deutsch;Tom Olson;A. Nagler;S. Slavin;R. Levine;A. Eldor
通讯作者：
A. Eldor
DOI：
10.1073/pnas.84.24.9035
发表时间：
1987-12-01
影响因子：
11.1
作者：
IKEBUCHI, K;WONG, GG;OGAWA, M
通讯作者：
OGAWA, M