The genetic liability to disability retirement: a 30-year follow-up study of 24,000 Finnish twins.
The genetic liability to disability retirement: a 30-year follow-up study of 24,000 Finnish twins.
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DOI：
10.1371/journal.pone.0003402
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发表时间：
2008
期刊：
影响因子：
3.7
通讯作者：
Kaprio, Jaakko
中科院分区：
文献类型：
--
作者：
Harkonmaki, Karoliina;Silventoinen, Karri;Levalahti, Esko;Pitkaniemi, Janne;Huunan-Seppala, Antti;Klaukka, Timo;Koskenvuo, Markku;Kaprio, Jaakko
以前没有进行过关于遗传因素对残疾退休责任的影响的研究。本研究的主要目的是调查遗传因素对最常见的医疗原因（包括抑郁症）导致的残疾退休的影响。研究样本包括24043名参与者（49.7%为女性），包括11186对完全同性双胞胎，其中3519对为同卵双生（MZ），7667对为异卵双生（DZ）。1975年1月1日至2004年12月31日期间退休事件的信息，包括诊断的残疾养恤金，来自芬兰全国官方养恤金登记册。采用MZ和DZ双生子的遗传易感性相关和离散时间相关脆弱性模型研究了残疾退休年龄的遗传易感性。30年累计残疾退休率为20%。在最佳拟合遗传模型下，任何医学原因引起的DPs的遗传力估计为0.36（95% CI 0.32-0.40），由于肌肉骨骼疾病0.37（0.30-0.43）、心血管疾病0.48（0.39-0.57）、精神障碍0.42（0.35-0.49）、其他原因0.24（0.17-0.31）。遗传因素的影响随着退休年龄的增加而减少。对于由抑郁症引起的DP，28%的方差由家庭成员共享的环境因素解释（95% CI 21-36），58%的方差由年龄段特定的环境因素解释（95% CI 44-71）。一个温和的遗传贡献的残疾退休的变化，由于任何医疗cause. The遗传效应似乎是更强的残疾退休的年轻年龄，这表明随着年龄的增长，不共享与家庭成员的环境因素的影响越来越大。家庭聚集在DP由于抑郁症是最好的解释共同的环境因素和遗传因素不需要考虑的模式，家庭聚集。
No previous studies on the effect of genetic factors on the liability to disability retirement have been carried out. The main aim of this study was to investigate the contribution of genetic factors on disability retirement due to the most common medical causes, including depressive disorders. The study sample consisted of 24 043 participants (49.7% women) consisting of 11 186 complete same-sex twin pairs including 3519 monozygotic (MZ) and 7667dizygotic (DZ) pairs. Information on retirement events during 1.1.1975–31.12.2004, including disability pensions (DPs) with diagnoses, was obtained from the Finnish nationwide official pension registers. Correlations in liability for MZ and DZ twins and discrete time correlated frailty model were used to investigate the genetic liability to age at disability retirement. The 30 year cumulative incidence of disability retirement was 20%. Under the best fitting genetic models, the heritability estimate for DPs due to any medical cause was 0.36 (95% CI 0.32–0.40), due to musculoskeletal disorders 0.37 (0.30–0.43), cardiovascular diseases 0.48 (0.39–0.57), mental disorders 0.42 (0.35–0.49) and all other reasons 0.24 (0.17–0.31). The effect of genetic factors decreased with increasing age of retirement. For DP due to depressive disorders, 28% of the variance was explained by environmental factors shared by family members (95% CI 21–36) and 58% of the variance by the age interval specific environmental factors (95% CI 44–71). A moderate genetic contribution to the variation of disability retirement due to any medical cause was found. The genetic effects appeared to be stronger at younger ages of disability retirement suggesting the increasing influence of environmental factors not shared with family members with increasing age. Familial aggregation in DPs due to depressive disorders was best explained by the common environmental factors and genetic factors were not needed to account for the pattern of familial aggregation.
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影响因子：
4.7
作者：
Appelberg, K;Romanov, K;Koskenvuo, M
通讯作者：
Koskenvuo, M
影响因子：
5.5
作者：
Fejer, R;Hartvigsen, J;Kyvik, KO
通讯作者：
Kyvik, KO
影响因子：
17.7
作者：
Kendler, KS;Gardner, CO;Prescott, CA
通讯作者：
Prescott, CA
影响因子：
17.7
作者：
Kieseppä, T;Partonen, T;Lönnqvist, J
通讯作者：
Lönnqvist, J
影响因子：
8.2
作者：
KAPRIO, J;TUOMILEHTO, J;KESANIEMI, YA
通讯作者：
KESANIEMI, YA