Comprehensive spatiotemporal analysis of early chick neural crest network genes.
Comprehensive spatiotemporal analysis of early chick neural crest network genes.
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DOI：
10.1002/dvdy.21881
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发表时间：
2009-03
影响因子：
2.5
通讯作者：
Bronner-Fraser, Marianne
中科院分区：
文献类型：
--
作者：
Khudyakov, Jane;Bronner-Fraser, Marianne
在神经板边缘的原肠形成过程中，早在迁移或分化之前，神经脊祖细胞的特化就开始了。神经脊细胞命运是通过逐渐激活在脊椎动物中似乎高度保守的离散转录因子组获得的；然而，作为神经脊发育的重要模型系统，对其表达的全面分析在鸡中一直缺乏。为了解决这个问题，我们分析了10个转录因子的表达，这些转录因子是神经板边界和神经脊命运的已知指定者，并在从原肠形成到神经脊迁移的不同发育阶段进行了比较。令人惊讶的是，我们发现大多数神经脊定义符在雏鸡的原肠发育过程中表达，与神经板边界定义符相伴并在相似的区域中表达。这表明这些分子之间的相互作用可能比之前认为的要早得多，这是解释功能研究的一个重要考虑因素。
Specification of neural crest progenitors begins during gastrulation at the neural plate border, long before migration or differentiation. Neural crest cell fate is acquired by progressive activation of discrete groups of transcription factors that appear to be highly conserved in vertebrates; however, comprehensive analysis of their expression has been lacking in chick, an important model system for neural crest development. To address this, we analyzed expression of ten transcription factors that are known specifiers of neural plate border and neural crest fate and compared them across developmental stages from gastrulation to neural crest migration. Surprisingly, we find that most neural crest specifiers are expressed during gastrulation in chick, concomitant with and in similar domains as neural plate border specifiers. This suggests that interactions between these molecules may occur much earlier than previously thought, an important consideration for interpretation of functional studies.
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影响因子：
64.8
作者：
Basch, ML;Bronner-Fraser, M;García-Castro, MI
通讯作者：
García-Castro, MI
影响因子：
56.9
作者：
NIETO, MA;SARGENT, MG;COOKE, J
通讯作者：
COOKE, J
影响因子：
4.6
作者：
Sakai, D;Suzuki, T;Wakamatsu, Y
通讯作者：
Wakamatsu, Y
影响因子：
2.5
作者：
Brown, ST;Wang, JM;Groves, AK
通讯作者：
Groves, AK
影响因子：
2.5
作者：
Luo, T;Matsuo-Takasaki, M;Sargent, TD
通讯作者：
Sargent, TD