Dairy consumption and risks of total and site-specific cancers in Chinese adults: an 11-year prospective study of 0.5 million people.
Dairy consumption and risks of total and site-specific cancers in Chinese adults: an 11-year prospective study of 0.5 million people.
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DOI：
10.1186/s12916-022-02330-3
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发表时间：
2022-05-06
期刊：
影响因子：
9.3
通讯作者：
Chen, Zhengming
中科院分区：
文献类型：
--
作者：
Kakkoura, Maria G.;Du, Huaidong;Guo, Yu;Yu, Canqing;Yang, Ling;Pei, Pei;Chen, Yiping;Sansome, Sam;Chan, Wing Ching;Yang, Xiaoming;Fan, Lei;Lv, Jun;Chen, Junshi;Li, Liming;Key, Timothy J.;Chen, Zhengming
以前主要针对西方人群的研究报告了乳制品消费与某些癌症的对比关系，包括与前列腺癌的正相关以及与结直肠癌和绝经前乳腺癌的负相关。然而，来自中国的数据有限，中国的癌症发病率和乳制品消费水平与西方人群有很大差异。中国嘉道理生物样本库的前瞻性研究在2004-2008年期间招募了来自中国10个不同地区（5个城市，5个农村）的约50万成年人。在基线和随后的再调查时，使用经验证的访谈者管理的基于笔记本电脑的食物频率问卷，收集主要食物组（包括乳制品）的消费频率。为了量化乳制品摄入量与癌症风险的线性关系，并考虑回归稀释偏倚，通过结合基线和第二次再调查的消费水平估计每个基线组的平均日常消费量。在平均10.8年（SD 2.0）的随访期间，在基线时没有癌症的510，146名参与者中记录了29，277例癌症事件。考克斯回归分析与日常乳制品摄入量相关的癌症发病率按风险年龄、性别和地区分层，并调整了癌症家族史、教育、收入、酒精摄入、吸烟、体育活动、大豆和新鲜水果摄入以及体重指数。总体而言，20.4%的参与者报告经常食用乳制品（主要是牛奶）（即≥1天/周），普通消费者的估计平均消费量为80.8 g/天，所有参与者为37.9 g/天。乳制品消费量与总癌症和某些特定部位癌症的风险存在显着正相关，每50 g/天日常消费量的校正HR为1.07（95% CI 1.04-1.10），1.12（1.02-1.22）、1.19总癌、肝癌（n = 3191）、女性乳腺癌（n = 2582）和淋巴瘤（n=915）的平均生存期分别为1.01-1.41和1.17（1.07-1.29）。然而，在校正多重检验后，与淋巴瘤的相关性没有统计学意义。未观察到结直肠癌（n = 3350，1.08 [1.00-1.17]）或其他部位特异性癌症的显著相关性。在乳制品消费量相对低于西方人群的中国成年人中，较高的乳制品摄入量与肝癌，女性乳腺癌和淋巴瘤的风险较高相关。在线版本包含补充材料，可通过10.1186/s12916-022-02330-3获取。
Previous studies of primarily Western populations have reported contrasting associations of dairy consumption with certain cancers, including a positive association with prostate cancer and inverse associations with colorectal and premenopausal breast cancers. However, there are limited data from China where cancer rates and levels of dairy consumption differ importantly from those in Western populations. The prospective China Kadoorie Biobank study recruited ~0.5 million adults from ten diverse (five urban, five rural) areas across China during 2004–2008. Consumption frequency of major food groups, including dairy products, was collected at baseline and subsequent resurveys, using a validated interviewer-administered laptop-based food frequency questionnaire. To quantify the linear association of dairy intake and cancer risk and to account for regression dilution bias, the mean usual consumption amount for each baseline group was estimated via combining the consumption level at both baseline and the second resurvey. During a mean follow-up of 10.8 (SD 2.0) years, 29,277 incident cancer cases were recorded among the 510,146 participants who were free of cancer at baseline. Cox regression analyses for incident cancers associated with usual dairy intake were stratified by age-at-risk, sex and region and adjusted for cancer family history, education, income, alcohol intake, smoking, physical activity, soy and fresh fruit intake, and body mass index. Overall, 20.4% of participants reported consuming dairy products (mainly milk) regularly (i.e. ≥1 day/week), with the estimated mean consumption of 80.8 g/day among regular consumers and of 37.9 g/day among all participants. There were significant positive associations of dairy consumption with risks of total and certain site-specific cancers, with adjusted HRs per 50 g/day usual consumption being 1.07 (95% CI 1.04–1.10), 1.12 (1.02–1.22), 1.19 (1.01–1.41) and 1.17 (1.07–1.29) for total cancer, liver cancer (n = 3191), female breast cancer (n = 2582) and lymphoma (n=915), respectively. However, the association with lymphoma was not statistically significant after correcting for multiple testing. No significant associations were observed for colorectal cancer (n = 3350, 1.08 [1.00–1.17]) or other site-specific cancers. Among Chinese adults who had relatively lower dairy consumption than Western populations, higher dairy intake was associated with higher risks of liver cancer, female breast cancer and, possibly, lymphoma. The online version contains supplementary material available at 10.1186/s12916-022-02330-3.
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影响因子：
--
作者：
Kimura T
通讯作者：
Kimura T
影响因子：
7
作者：
He, Yuna;Yang, Xiaoguang;Yang, Yuexin
通讯作者：
Yang, Yuexin
中国的新鲜水果消费和主要的心血管疾病。
DOI：
10.1056/nejmoa1501451
发表时间：
2016-04-07
期刊：
The New England journal of medicine
影响因子：
--
作者：
Du H;Li L;Bennett D;Guo Y;Key TJ;Bian Z;Sherliker P;Gao H;Chen Y;Yang L;Chen J;Wang S;Du R;Su H;Collins R;Peto R;Chen Z;China Kadoorie Biobank Study
通讯作者：
China Kadoorie Biobank Study
影响因子：
7.7
作者：
Du H;Li L;Bennett D;Yang L;Guo Y;Key TJ;Bian Z;Chen Y;Walters RG;Millwood IY;Chen J;Wang J;Zhou X;Fang L;Li Y;Li X;Collins R;Peto R;Chen Z;China Kadoorie Biobank study
通讯作者：
China Kadoorie Biobank study
影响因子：
15.8
作者：
Du H;Li L;Bennett D;Guo Y;Turnbull I;Yang L;Bragg F;Bian Z;Chen Y;Chen J;Millwood IY;Sansome S;Ma L;Huang Y;Zhang N;Zheng X;Sun Q;Key TJ;Collins R;Peto R;Chen Z;China Kadoorie Biobank study
通讯作者：
China Kadoorie Biobank study