Fresh fruit consumption and all-cause and cause-specific mortality: findings from the China Kadoorie Biobank.
Fresh fruit consumption and all-cause and cause-specific mortality: findings from the China Kadoorie Biobank.
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DOI：
10.1093/ije/dyx042
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发表时间：
2017-10-01
影响因子：
7.7
通讯作者：
China Kadoorie Biobank study
中科院分区：
文献类型：
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作者：
Du H;Li L;Bennett D;Yang L;Guo Y;Key TJ;Bian Z;Chen Y;Walters RG;Millwood IY;Chen J;Wang J;Zhou X;Fang L;Li Y;Li X;Collins R;Peto R;Chen Z;China Kadoorie Biobank study
更多的水果消费与降低心血管疾病（CVD）的风险有关。然而，水果消费与全因死亡率以及心血管疾病亚型和主要非血管疾病死亡率的关系仍然存在很大的不确定性，尤其是在中国。2004-08年，中国嘉道理生物样本库研究在全国范围内招募了来自中国10个不同地区的超过50万名30-79岁的成年人。新鲜水果的消费量估计使用访问者管理的电子问卷，死亡率数据收集从死亡登记处。在基线时没有重大慢性疾病的462342名参与者中，在2007年的随访期间记录了17894例死亡。考克斯回归得出了与水果消费相关的全因和特定原因死亡率的校正率比（RR）。在基线时，28%的参与者报告每周食用水果≥ 4天（普通消费者），6%的人报告从不/很少食用水果（非消费者）。与非消费者相比，经常消费者的全因死亡率降低了27% [RR = 0.73，95%置信区间（CI）0.70-0.76]，心血管疾病死亡率降低了34（n = 6166; RR = 0.66，0.61-0.71），癌症死亡率降低17%（n = 6796; RR = 0.83，0.78-0.89）和慢性阻塞性肺疾病（COPD）死亡率降低42%（n = 1119; RR = 0.58，0.47-0.71）。对于上述各项，与消耗量存在近似对数线性剂量-反应关系。对于特定部位癌症的死亡率，水果消费与消化道癌症呈负相关（n = 2265; RR = 0.72，0.64-0.81），特别是食管癌（n = 801; RR = 0.65，0.50-0.83），但与肺癌或肝癌无关。在中国成年人中，较高的新鲜水果消费量与几种主要血管和非血管疾病的死亡率显著降低相关。鉴于目前中国人口水果消费水平较低，增加水果消费对健康有益。
Higher fruit consumption is associated with lower risk of cardiovascular disease (CVD). Substantial uncertainties remain, however, about the associations of fruit consumption with all-cause mortality and mortality from subtypes of CVD and major non-vascular diseases, especially in China. In 2004–08, the nationwide China Kadoorie Biobank Study recruited > 0.5 million adults aged 30–79 years from 10 diverse localities in China. Fresh fruit consumption was estimated using an interviewer-administered electronic questionnaire, and mortality data were collected from death registries. Among the 462 342 participants who were free of major chronic diseases at baseline, 17 894 deaths were recorded during ∼ 7 years of follow-up. Cox regression yielded adjusted rate ratios (RRs) for all-cause and cause-specific mortality associated with fruit consumption. At baseline, 28% of participants reported consuming fruit ≥ 4 days/week (regular consumers) and 6% reported never/rarely consuming fruit (non-consumers). Compared with non-consumers, regular consumers had 27% [RR = 0.73, 95% confidence interval (CI) 0.70–0.76] lower all-cause mortality, 34% lower CVD mortality (n = 6166; RR = 0.66, 0.61–0.71), 17% lower cancer mortality (n = 6796; RR = 0.83, 0.78–0.89) and 42% lower mortality from chronic obstructive pulmonary disease (COPD) (n = 1119; RR = 0.58, 0.47–0.71). For each of the above, there was an approximately log-linear dose-response relationship with amount consumed. For mortality from site-specific cancers, fruit consumption was inversely associated with digestive tract cancer (n = 2265; RR = 0.72, 0.64–0.81), particularly oesophageal cancer (n = 801; RR = 0.65, 0.50–0.83), but not with cancer of lung or liver. Among Chinese adults, higher fresh fruit consumption was associated with significantly lower mortality from several major vascular and non-vascular diseases. Given the current low population level of fruit consumption, substantial health benefits could be gained from increased fruit consumption in China.
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DOI：
10.1136/bmj.g4490
发表时间：
2014-07-29
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Wang X;Ouyang Y;Liu J;Zhu M;Zhao G;Bao W;Hu FB
通讯作者：
Hu FB
影响因子：
3.7
作者：
Aasheim ET;Sharp SJ;Appleby PN;Shipley MJ;Lentjes MA;Khaw KT;Brunner E;Key TJ;Wareham NJ
通讯作者：
Wareham NJ
DOI：
10.1016/s0140-6736(15)00340-2
发表时间：
2015-10-10
期刊：
Lancet (London, England)
影响因子：
--
作者：
Chen Z;Peto R;Zhou M;Iona A;Smith M;Yang L;Guo Y;Chen Y;Bian Z;Lancaster G;Sherliker P;Pang S;Wang H;Su H;Wu M;Wu X;Chen J;Collins R;Li L;China Kadoorie Biobank (CKB) collaborative group
通讯作者：
China Kadoorie Biobank (CKB) collaborative group
影响因子：
8.3
作者：
Hu, Dan;Huang, Junqian;Qu, Yan
通讯作者：
Qu, Yan
影响因子：
2.4
作者：
Wakai, Kenji;Matsuo, Keitaro;Tsugane, Shoichiro
通讯作者：
Tsugane, Shoichiro