Resilience, pain, and the brain: Relationships differ by sociodemographics.
Resilience, pain, and the brain: Relationships differ by sociodemographics.
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DOI：
10.1002/jnr.24790
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发表时间：
2021-05
影响因子：
4.2
通讯作者：
Sibille KT
中科院分区：
文献类型：
--
作者：
Tanner JJ;Johnson AJ;Terry EL;Cardoso J;Garvan C;Staud R;Deutsch G;Deshpande H;Lai S;Addison A;Redden D;Goodin BR;Price CC;Fillingim RB;Sibille KT
慢性肌肉骨骼疼痛(MSK)给个人造成残疾，给社会带来负担。在考虑慢性疼痛强度的个体中，端粒长度和弹性之间的关系被报道。虽然慢性疼痛与大脑变化有关，但人们对弹性的神经生物学接口知之甚少。在一组患有慢性MSK疼痛的患者中，我们检查了先前调查的弹性指数、临床疼痛和功能测量以及与疼痛相关的大脑结构之间的关系，并考虑了性别和种族/种族。对16 6名45-85岁的非西班牙裔黑人和非西班牙裔白人成年人在过去3个月中的疼痛≥1身体部位(S)进行了横断面分析。完成了临床疼痛和功能、生物行为和心理社会复原力以及结构磁共振的测量。我们的发现表明，较高的弹性水平与较低的临床疼痛和功能限制水平相关。在右侧杏仁核复合体、双侧丘脑和中央后回，弹性、种族/种族和/或性别与疼痛相关的脑灰质结构显示出显著的相关性。我们的发现提供了令人信服的证据，即为了破译慢性疼痛和相关保护因素的神经生物学代码，重要的是改进慢性疼痛的表型；在研究中纳入平等的女性代表，包括按性别分层的分析，并考虑其他社会人口因素。
Chronic musculoskeletal (MSK) pain is disabling to individuals and burdensome to society. A relationship between telomere length and resilience was reported in individuals with consideration for chronic pain intensity. While chronic pain associates with brain changes, little is known regarding the neurobiological interface of resilience. In a group of individuals with chronic MSK pain, we examined the relationships between a previously investigated resilience index, clinical pain and functioning measures, and pain-related brain structures, with consideration for sex and ethnicity/race. A cross-sectional analysis of 166 non-Hispanic Black and non-Hispanic White adults, 45–85 years of age with pain ≥ 1 body site (s) over the past 3 months was completed. Measures of clinical pain and functioning, biobehavioral and psychosocial resilience, and structural MRI were completed. Our findings indicate higher levels of resilience associate with lower levels of clinical pain and functional limitations. Significant associations between resilience, ethnicity/race, and/or sex, and pain-related brain gray matter structure were demonstrated in the right amygdaloid complex, bilateral thalamus, and postcentral gyrus. Our findings provide compelling evidence that in order to decipher the neurobiological code of chronic pain and related protective factors, it will be important to improve how chronic pain is phenotyped; to include an equal representation of females in studies including analyses stratifying by sex, and to consider other sociodemographic factors.
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影响因子：
7.4
作者：
Bushnell MC;Case LK;Ceko M;Cotton VA;Gracely JL;Low LA;Pitcher MH;Villemure C
通讯作者：
Villemure C
影响因子：
1.7
作者：
Apkarian AV
通讯作者：
Apkarian AV
影响因子：
5.3
作者：
Apkarian, AV;Sosa, Y;Gitelman, DR
通讯作者：
Gitelman, DR
影响因子：
3.7
作者：
Baliki MN;Schnitzer TJ;Bauer WR;Apkarian AV
通讯作者：
Apkarian AV
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y