Tracking the return of Aedes aegypti to Brazil, the major vector of the dengue, chikungunya and Zika viruses.
Tracking the return of Aedes aegypti to Brazil, the major vector of the dengue, chikungunya and Zika viruses.
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DOI：
10.1371/journal.pntd.0005653
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发表时间：
2017-07
影响因子：
3.8
通讯作者：
Powell JR
中科院分区：
文献类型：
--
作者：
Kotsakiozi P;Gloria-Soria A;Caccone A;Evans B;Schama R;Martins AJ;Powell JR
埃及伊蚊，俗称“黄热病蚊子”，今天是一个重大的医疗问题，主要是作为登革热，基孔肯雅和寨卡病毒的主要载体，尽管黄热病在一些地区仍然是一个严重的健康问题。Ae的历史巴西的埃及人特别令人感兴趣，因为该国在20世纪40年代至50年代期间进行了有据可查的根除计划。在运动停止后，蚊子在20世纪70年代初迅速恢复，在过去30年中报告了几次登革热疫情。巴西可以被认为是受黄热病蚊子影响最严重的国家，因为该国报告的登革热，基孔肯雅和寨卡病例数量很高，此前曾被宣布为"无Ae"。埃及"。我们利用12个微卫星标记来推断巴西山羊草的遗传结构。埃及人口、遗传变异性、与邻近地理区域的遗传亲缘关系以及它们到达和传播的时间。这使我们能够重建他们最近的历史，并评估在巴西的再现是从邻近的非根除地区重新入侵的结果，还是从根除计划幸存下来的当地避难所重新出现。我们的研究结果表明，分离的北方和南部的巴西Ae的遗传断裂。埃及种群，每个集群内进一步的遗传分化，特别是在巴西南部。根据我们的研究结果，从非根除地区的再入侵是最有可能的情况下，Ae的再现。埃及在巴西虽然北方集群的种群可能早在20世纪70年代就来自委内瑞拉种群，但南方种群似乎最近来自北方巴西地区。在南部和北方集群中也发现了可能的进入点，这可以为控制和监测这一重要虫媒病毒的战略提供信息。埃及伊蚊（"黄热病蚊子"）是引起极大医学关注的，因为它是引起登革热、基孔肯雅病和寨卡的重要病毒的主要媒介，并且越来越多地再次传播黄热病。由于寨卡病毒于2015年在巴西爆发，并在中美洲/南美洲和加勒比地区迅速蔓延，报告了数百万例病例，这种蚊子已经获得了特殊的恶名。到目前为止，巴西不仅是寨卡病毒感染最严重的国家，也是登革热和基孔肯雅病的受害者。有趣的是，在20世纪50年代，巴西被宣布为"没有Ae。埃及"后，一个有据可查的根除计划。然而，在过去的45年里，Ae。埃及伊蚊在巴西再次出现，造成几次登革热疫情，据报有数百万病例。在这里，我们使用遗传数据来研究Ae的再现。埃及伊蚊在巴西的灭绝事件。我们的研究结果支持重新入侵;来自委内瑞拉未根除地区的蚊子入侵了巴西北部，后来向南扩展了它们的分布。我们还确定了巴西的具体地点，作为可能的入境点。这些知识可以为控制病媒及其传播疾病的传播战略提供信息。
Aedes aegypti, commonly known as “the yellow fever mosquito”, is of great medical concern today primarily as the major vector of dengue, chikungunya and Zika viruses, although yellow fever remains a serious health concern in some regions. The history of Ae. aegypti in Brazil is of particular interest because the country was subjected to a well-documented eradication program during 1940s-1950s. After cessation of the campaign, the mosquito quickly re-established in the early 1970s with several dengue outbreaks reported during the last 30 years. Brazil can be considered the country suffering the most from the yellow fever mosquito, given the high number of dengue, chikungunya and Zika cases reported in the country, after having once been declared “free of Ae. aegypti”. We used 12 microsatellite markers to infer the genetic structure of Brazilian Ae. aegypti populations, genetic variability, genetic affinities with neighboring geographic areas, and the timing of their arrival and spread. This enabled us to reconstruct their recent history and evaluate whether the reappearance in Brazil was the result of re-invasion from neighboring non-eradicated areas or re-emergence from local refugia surviving the eradication program. Our results indicate a genetic break separating the northern and southern Brazilian Ae. aegypti populations, with further genetic differentiation within each cluster, especially in southern Brazil. Based on our results, re-invasions from non-eradicated regions are the most likely scenario for the reappearance of Ae. aegypti in Brazil. While populations in the northern cluster are likely to have descended from Venezuela populations as early as the 1970s, southern populations seem to have derived more recently from northern Brazilian areas. Possible entry points are also revealed within both southern and northern clusters that could inform strategies to control and monitor this important arbovirus vector. Aedes aegypti (“yellow fever mosquito”) is of great medical concern because it is the primary vector of important viruses causing dengue fever, chikungunya and Zika, as well as increasingly transmitting yellow fever once again. Due to the Zika outbreak, which started in Brazil in 2015 and rapidly spread with million cases reported in Central/South America and the Caribbean, this mosquito has attained special notoriety. Brazil is by far the most affected country not only by Zika, but also by dengue and chikungunya. Interestingly, in 1950s Brazil had been declared “free of Ae. aegypti” after a well-documented eradication program. However, during the last 45 years Ae. aegypti reappeared in Brazil causing several dengue outbreaks, with millions of reported cases. Here, we used genetic data to study the reappearance of Ae. aegypti in Brazil after the putative eradication event. Our results support re-invasion; mosquitoes from the non-eradicated areas in Venezuela invaded North Brazil, later expanding their distribution southwards. We also identify specific locations in Brazil, as possible entry points. This knowledge can inform strategies to control the spread of the vector and of the diseases it transmits.
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人类的影响塑造了埃及埃及，登革热和黄热病蚊子的历史和最新进化。
DOI：
10.1111/evo.12281
发表时间：
2014-02
期刊：
Evolution; international journal of organic evolution
影响因子：
--
作者：
Brown JE;Evans BR;Zheng W;Obas V;Barrera-Martinez L;Egizi A;Zhao H;Caccone A;Powell JR
通讯作者：
Powell JR
影响因子：
2.1
作者：
Paduan, Karina dos Santos;Araújo-Júnior, João P.;Ribolla, Paulo E.M.
通讯作者：
Ribolla, Paulo E.M.
影响因子：
5.8
作者：
Cornuet, Jean-Marie;Pudlo, Pierre;Estoup, Arnaud
通讯作者：
Estoup, Arnaud
影响因子：
2.9
作者：
Jensen, JL;Bohonak, AJ;Kelley, ST
通讯作者：
Kelley, ST
DOI：
10.1073/pnas.91.8.3166
发表时间：
1994-04-12
影响因子：
11.1
作者：
DIRIENZO, A;PETERSON, AC;FREIMER, NB
通讯作者：
FREIMER, NB