Impulsivity-related brain volume deficits in schizophrenia-addiction comorbidity.
Impulsivity-related brain volume deficits in schizophrenia-addiction comorbidity.
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精神分裂症成瘾合并症中与冲动相关的脑容量缺陷
DOI：
10.1093/brain/awq153
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Gizewski
中科院分区：
文献类型：
--
作者：
Schiffer;Müller;Scherbaum;Forsting;Wiltfang;Leygraf;Gizewski
尽管精神分裂症患者合并药物滥用的患病率很高，但对大脑可能产生的影响知之甚少。因此，我们的目标是确定成瘾和非成瘾精神分裂症患者是否患有不同的大脑缺陷。我们特别感兴趣的是确定灰质体积是否受到冲动的影响。我们假设（共病）物质滥用与冲动性增强有关，这种冲动性增强与前额叶灰质体积缺陷有关。我们采用了基于体素的形态测量方法，以及神经心理学评估的执行功能和特质冲动的51名参与者（年龄范围23-55）。精神分裂症组包括24名患者（12名偏执型精神分裂症患者和12名其他共病物质使用障碍患者）。对照组包括27名非精神分裂症患者，年龄和教育程度相匹配（14名健康人和13名物质使用障碍患者）。与健康对照组相比，在所有患者组中均发现总灰质体积缺陷，但在两个成瘾组中最大（108%）。虽然外侧眶额和颞区的灰质体积损失受到精神分裂症的影响，内侧眶额，前扣带回和额极皮质的体积减少与成瘾有关。与非成瘾性精神分裂症患者相比，共病患者的前扣带回、额极和上级顶叶区域体积显著减小。此外，他们表现出增加的非计划冲动，是负相关的灰质体积在同一地区，除了顶叶的。目前的研究表明，严重的灰质体积和功能性执行缺陷的精神分裂症，这只是部分加剧了共病成瘾。然而，非计划冲动和前扣带回和额极灰质体积之间的关系指向一个特定的结构-功能关系，似乎是受损的精神分裂症成瘾共病。
Despite a high prevalence of schizophrenia patients with comorbid substance abuse, little is known about possible impacts on the brain. Hence, our goal was to determine whether addicted and non-addicted schizophrenic patients suffer from different brain deficits. We were especially interested to determine if grey matter volumes were affected by impulsivity. We hypothesized that (comorbid) substance abuse would be associated with enhanced impulsivity and that this enhanced impulsivity would be related to grey matter volume deficits in prefrontal areas. We employed a voxel-based morphometry approach as well as neuropsychological assessment of executive functions and trait impulsivity in 51 participants (age range 23–55). The schizophrenia group comprised 24 patients (12 patients with paranoid schizophrenia and 12 with additional comorbid substance use disorders). The comparison group comprised 27 non-schizophrenic individuals, matched by age and education (14 healthy individuals and 13 patients with substance use disorders). Total grey matter volume deficits were found in all patient groups as compared with healthy controls but were largest (∼8%) in both addicted groups. While grey matter volume losses in lateral orbitofrontal and temporal regions were affected by schizophrenia, volume decreases of the medial orbitofrontal, anterior cingulate and frontopolar cortex were associated with addiction. Compared with non-addicted schizophrenics, comorbid patients showed significant volume decreases in anterior cingulate, frontopolar and superior parietal regions. Additionally, they showed an increased non-planning impulsivity that was negatively related to grey matter volumes in the same regions, except for parietal ones. The present study indicates severe grey matter volume and functional executive deficits in schizophrenia, which were only partially exacerbated by comorbid addiction. However, the relationship between non-planning impulsivity and anterior cingulate and frontopolar grey matter volumes points to a specific structure–function relationship that seems to be impaired in schizophrenia-addiction comorbidity.
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影响因子：
--
作者：
Minzenberg, Michael J.;Laird, Angela R.;Thelen, Sarah;Carter, Cameron S.;Glahn, David C.
通讯作者：
Glahn, David C.
影响因子：
4.8
作者：
Matsuo, Koji;Nicoletti, Mark;Soares, Jair C.
通讯作者：
Soares, Jair C.
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影响因子：
4.3
作者：
J. Addington;D. Addington
通讯作者：
D. Addington
多物质滥用者前额叶体积较小：磁共振成像研究
影响因子：
7.6
作者：
Xiang Liu;J. Matochik;J. Cadet;E. London
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E. London
影响因子：
17.7
作者：
Tarter, RE;Kirisci, L;Clark, D
通讯作者：
Clark, D