The interface of functional biotribology and regenerative medicine in synovial joints.
The interface of functional biotribology and regenerative medicine in synovial joints.
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DOI：
10.1089/ten.teb.2008.0047
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发表时间：
2008-09
期刊：
影响因子：
--
通讯作者：
Reddi AH
中科院分区：
文献类型：
--
作者：
Neu CP;Komvopoulos K;Reddi AH
生物摩擦学是生物表面滑动接触的科学，包括摩擦，磨损和相互作用表面的润滑的概念。这个生物科学领域已经从摩擦学的经典领域出现，并且对许多组织的正常功能至关重要，包括关节软骨，血管，心脏，肌腱，韧带和皮肤。令人惊讶的是，在组织工程和再生医学领域中，对表面特征的恢复给予了相对较少的关注，再生医学是设计和制造新组织的科学，用于依赖于诱导信号、响应干细胞和细胞外基质支架的受损或患病器官的功能恢复。与古代文明相似（C。公元前3000年）随着轮式车辆、运输重物的雪橇和润滑剂的出现，现代生物摩擦学家必须致力于恢复再生组织的表面特性，并开发具有最佳摩擦学性能的新型生物材料。本文的目的是突出功能性生物摩擦学在体表生理学中的重要性，并全面概述与再生医学相关的未解决问题和争议。特别关注的是润滑的分子基础，润滑分子的机械和生物化学调节，以及需要研究关节软骨的磨损过程，特别是在退行性疾病，如骨关节炎。表面工程的替代组织表现出低摩擦和高耐磨性检查使用关节软骨作为一个说明性的模型系统。
Biotribology is the science of biological surfaces in sliding contact encompassing the concepts of friction, wear, and lubrication of interacting surfaces. This bioscience field has emerged from the classical field of tribology and is of paramount importance to the normal function of numerous tissues, including articular cartilage, blood vessels, heart, tendons, ligaments, and skin. Surprisingly, relatively little attention has been given to the restoration of surface characteristics in the fields of tissue engineering and regenerative medicine—the science of design and manufacture of new tissues for the functional restoration of impaired or diseased organs that depend on inductive signals, responding stem cells, and extracellular matrix scaffolding. Analogous to ancient civilizations (c. 3000 B.C.) that introduced wheeled vehicles, sledges for transporting heavy blocks, and lubricants, modern biotribologists must aim to restore surface characteristics to regenerated tissues and develop novel biomaterials with optimal tribological properties. The objective of this article is to highlight the significance of functional biotribology in the physiology of body surfaces and provide a comprehensive overview of unresolved issues and controversies as it relates to regenerative medicine. Specific attention is placed on the molecular basis of lubrication, mechanical and biochemical regulation of lubricating molecules, and the need to study wear processes in articular cartilage, especially in light of degenerative diseases, such as osteoarthritis. Surface engineering of replacement tissues exhibiting low friction and high wear resistance is examined using articular cartilage as an illustrative model system.
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影响因子：
--
作者：
Grad, S;Lee, CR;Alini, M
通讯作者：
Alini, M
影响因子：
27.4
作者：
HILLS, BA;BUTLER, BD
通讯作者：
BUTLER, BD
影响因子：
--
作者：
Englert, C;McGowan, KB;Sah, RL
通讯作者：
Sah, RL
DOI：
10.1016/0304-4165(67)90113-4
发表时间：
1967-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
BALAZS, EA;PHILLIPS, GO;YOUNG, MD
通讯作者：
YOUNG, MD
影响因子：
27.4
作者：
CHARNLEY, J
通讯作者：
CHARNLEY, J