Effect of blood transfusions on cognitive development in very low birth weight infants.
Effect of blood transfusions on cognitive development in very low birth weight infants.
复制标题
输血对极低出生体重儿认知发育的影响。
DOI：
10.1038/s41372-021-00997-9
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Ohls RK
中科院分区：
文献类型：
--
作者：
Shah P;Cannon DC;Lowe JR;Phillips J;Christensen RD;Kamath-Rayne B;Rosenberg A;Wiedmeier S;Patel S;Winter S;Baker S;Ohls RK
早产儿经常接受红细胞输注;然而，输注对认知的影响尚不清楚。我们评估了一项随机试验中红细胞生成刺激剂（ESA）的早产儿输血和认知结果之间的关系。早产儿在最初住院期间随机接受ESA或安慰剂治疗，并记录输血情况。在18-22个月（56名ESA，24名安慰剂）和3.5-4岁（39名ESA，14名安慰剂）时使用标准认知发育测试对儿童进行评估。18-22个月时的认知评分与输血量呈负相关（p=0.02）。在接受≥1次输血的患者中，ESA治疗组的认知评分显著较高（p=0.003）。在3.5-4岁时，输血与认知评分无关。在安慰剂组中，输血儿童在18-22个月时的认知评分低于未输血儿童。在ESA组中，认知评分没有因输血状态而不同，这表明ESA提供了神经保护。
Preterm infants frequently receive red cell transfusions; however, the effect of transfusions on cognition is unclear. We evaluated the relationship between transfusions and cognitive outcomes in preterm infants enrolled in a randomized trial of erythropoiesis stimulating agents (ESAs). Preterm infants were randomized to ESAs or placebo during initial hospitalization, and transfusions recorded. Children were evaluated using standard developmental tests of cognition at 18–22 months (56 ESA, 24 placebo) and 3.5–4 years (39 ESA, 14 placebo) Cognitive scores at 18–22 months were inversely correlated with transfusion volume at (p=0.02). Among those receiving ≥1 transfusion, cognitive scores were significantly higher in the ESA-treated group (p=0.003). At 3.5–4 years, transfusions weren’t correlated with cognitive scores. In the placebo group, transfused children had lower cognitive scores than did non-transfused children at 18–22 months. In the ESA group, cognitive scores did not differ by transfusion status, suggesting ESAs provide neuroprotection.
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