DNA aptamer functionalized nanomaterials for intracellular analysis, cancer cell imaging and drug delivery.
DNA aptamer functionalized nanomaterials for intracellular analysis, cancer cell imaging and drug delivery.
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DOI：
10.1016/j.cbpa.2012.03.016
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发表时间：
2012-08
影响因子：
7.8
通讯作者：
Lu, Yi
中科院分区：
文献类型：
--
作者：
Xing, Hang;Ngo Yin Wong;Xiang, Yu;Lu, Yi
用于细胞应用的纳米材料金属纳米颗粒因其合成简单、易于修饰和生物相容性而被广泛用于细胞摄取和分析的研究。对于细胞分析的应用，金和银纳米粒子由于其优异的等离子体特性而特别常见，这使得局域表面等离子体共振 (LSPR) 在表面增强拉曼光谱等应用中取得了重大进展 [4]。当靠近等离子体金属表面时，由于等离子体“热点”的电磁增强，拉曼信号可以实现 1014 次增强。纳米颗粒[5]、纳米壳[6]、纳米花[7]、纳米棒[8]和许多其他纳米结构[9]最近都因其在细胞成像、摄取机制和各种分析物检测中的等离子体特性而被探索[10]。读者可阅读其他最近的评论，重点关注纳米粒子在细胞分析中的 SERS/等离子体应用 [11]。
Nanomaterials for cellular applications Metal nanoparticles have been used widely for the studies of cellular uptake and analysis owing to their simple synthesis, facile modifications, and biocompatibility. For applications in cellular analysis, gold and silver nanoparticles have been especially common owing to their excellent plasmonic properties, which have enabled significant advances in localized surface plasmon resonance (LSPR) for applications such as surface enhanced Raman spectroscopy [4]. When in close proximity to the surface of a plasmonic metal, the Raman signal can achieve 1014 enhancements, owing to electromagnetic enhancements from plasmonic ‘hot spots’. Nanoparticles [5], nanoshells [6], nanoflowers [7], nanorods [8], and many other nanostructures [9] have all recently been explored for their plasmonic properties in cell imaging, uptake mechanisms, and detection of various analytes [10]. The reader is directed to other recent reviews that focus on SERS/plasmonic applications of nanoparticles for cellular analysis [11].
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影响因子：
15
作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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影响因子：
62.1
作者：
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通讯作者：
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影响因子：
13.3
作者：
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