Theranostic nanoshells: from probe design to imaging and treatment of cancer.
Theranostic nanoshells: from probe design to imaging and treatment of cancer.
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DOI：
10.1021/ar200023x
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发表时间：
2011-10-18
影响因子：
18.3
通讯作者：
Halas, Naomi J.
中科院分区：
文献类型：
--
作者：
Bardhan, Rizia;Lal, Surbhi;Joshi, Amit;Halas, Naomi J.
治疗方面的最新进展扩大了我们设计和构建多功能纳米颗粒的能力，最终将使我们能够在单一的临床程序中成像和治疗疾病。由于纳米科学和生物医学的这种融合，在单个纳米尺度的复合体中结合了靶向、治疗和诊断功能的医用纳米颗粒应运而生。在过去的十年里，随着纳米壳作为一种有前途的癌症治疗和生物成像增强工具的出现，金纳米壳-球形、二氧化硅核、金壳纳米颗粒-的声学能力引起了极大的关注。本文介绍了基于纳米壳层的热敏剂的设计和合成、它们的等离子体衍生光学性质及其相应的应用。纳米壳在共振光的照射下，要么是强光吸收体，要么是散射体，这些特性赋予了它们独特的能力。在这篇文章中，我们讨论了导致纳米壳层光热响应的基本物理原理。阐述了纳米壳层诱导弱近红外荧光团荧光增强的光物理机制。然后，我们描述了纳米壳作为造影剂在活体乳腺癌细胞光学相干断层扫描中的应用。我们还考察了纳米壳层作为近红外荧光和磁共振成像(MRI)结合光热消融癌细胞的多模式热敏探针的最新进展。讨论了纳米壳化合物的设计和制备，并描述了它们在加入磁共振对比剂时增强荧光团的光致发光的能力。我们展示了体内多模式纳米壳的治疗潜力，用于对动物模型中的皮下乳腺癌肿瘤进行成像，以及它们在各种组织中的生物分布。然后我们讨论了纳米壳作为光触发基因治疗载体的潜力。纳米壳层的等离子体性质使其成为高效的光控递送载体，为基于纳米颗粒的基因治疗方法的空间控制特性增加了时间控制。我们描述了DNA偶联纳米壳复合体的制备，并比较了光诱导和热诱导DNA释放的效率。我们研究了光触发的DAPI(4‘，6-二氨基-2-苯基吲哚)分子的释放，这种分子可逆地与双链DNA结合，以可视化细胞内光诱导的释放。最后，我们展望了基于纳米壳层的治疗疗法的未来前景，治疗疗法纳米医学在未来十年的潜在影响和近期挑战。
Recent advances in theranostics have expanded our ability to design and construct multifunctional nanoparticles that will ultimately allow us to image and treat diseases in a single clinical procedure. Theranostic nanoparticles, combining targeting, therapeutic and diagnostic functions within a single nanoscale complex, have emerged as a result of this confluence of nanoscience and biomedicine. The theranostic capabilities of gold nanoshells -spherical, silica core, gold shell nanoparticles- have attracted tremendous attention over the past decade as nanoshells have emerged as a promising tool for cancer therapy and bioimaging enhancement. This account examines the design and synthesis of nanoshell-based theranostic agents, their plasmon-derived optical properties and their corresponding applications. Nanoshells illuminated with resonant light are either strong optical absorbers or scatterers, properties which give rise to their unique capabilities. In this account, we discuss the underlying physical principles contributing to the photothermal response of nanoshells. We elucidate the photophysics of nanoshell-induced fluorescence enhancement of weak near-infrared fluorophores. We then describe the application of nanoshells as a contrast agent for optical coherence tomography of breast carcinoma cells in vivo. We also examine the recent progress of nanoshells as a multimodal theranostic probe for near-infrared fluorescence and magnetic resonance imaging (MRI) combined with photothermal ablation of cancer cells. The design and preparation of nanoshell complexes is discussed, and their ability to enhance the photoluminescence of fluorophores while incorporating MR contrast is described. We show the theranostic potential of the multimodal nanoshells in vivo for imaging subcutaneous breast cancer tumors in animal models and their biodistribution in various tissues. We then discuss the potential of nanoshells as light-triggered gene therapy vectors. The plasmonic properties of nanoshells make them highly effective as light controlled delivery vectors, adding temporal control to the spatial control characteristic of nanoparticle-based gene therapy approaches. We describe the fabrication of DNA-conjugated nanoshell complexes and compare the efficiency of light-induced and thermally-induced DNA release of DNA. We examine light-triggered release of DAPI (4',6-diamidino-2-phenylindole) molecules, which bind reversibly to double-stranded DNA, to visualize intracellular light-induced release. Finally, we look at future prospects of nanoshell-based theranostics, the potential impact and near-term challenges of theranostic nanomedicine in the next decade.
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影响因子：
38.3
作者：
通讯作者：
--
影响因子：
10.8
作者：
Bardhan R;Chen W;Bartels M;Perez-Torres C;Botero MF;McAninch RW;Contreras A;Schiff R;Pautler RG;Halas NJ;Joshi A
通讯作者：
Joshi A
DOI：
10.1073/pnas.2232479100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Hirsch, LR;Stafford, RJ;West, JL
通讯作者：
West, JL
影响因子：
10.8
作者：
Choi, Mi-Ran;Stanton-Maxey, Katie J.;Clare, Susan E.
通讯作者：
Clare, Susan E.
影响因子：
10.8
作者：
Gobin, Andre M.;Lee, Min Ho;West, Jennifer L.
通讯作者：
West, Jennifer L.