Different roles of axon guidance cues and patterned spontaneous activity in establishing receptive fields in the mouse superior colliculus.
Different roles of axon guidance cues and patterned spontaneous activity in establishing receptive fields in the mouse superior colliculus.
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DOI：
10.3389/fncir.2014.00023
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发表时间：
2014
影响因子：
3.5
通讯作者：
Cang J
中科院分区：
文献类型：
--
作者：
Liu M;Wang L;Cang J
上丘(SC)的视觉神经元在其感受野对亮(ON)和暗(OFF)刺激都有反应。这一感受野特性是由于视网膜神经节细胞向其在SC中的靶细胞的适当会聚。在这项研究中，我们比较了两个在视网膜定位映射方面存在缺陷的突变小鼠个体SC神经元的感受野结构：缺乏重要视网膜微血管轴突指导线索的ePhin-A基因敲除和改变了视网膜微血管投射活动依赖的精细化的nAChR-β2基因敲除。我们发现，即使在ePhin-A基因敲除中，接受野要大得多，但它们的开关重叠保持不变。这些神经元对刺激方向和方向也表现出正常水平的选择性。相比之下，在β2基因敲除中，开关重叠被打破。再加上之前在β2基因敲除小鼠中发现的方向和取向选择性中断，我们的结果表明，分子指导线索和活动依赖的过程在SC接受野特性的发展中扮演不同的角色。
Visual neurons in the superior colliculus (SC) respond to both bright (On) and dark (Off) stimuli in their receptive fields. This receptive field property is due to proper convergence of On- and Off-centered retinal ganglion cells to their target cells in the SC. In this study, we have compared the receptive field structure of individual SC neurons in two lines of mutant mice that are deficient in retinotopic mapping: the ephrin-A knockouts that lack important retinocollicular axonal guidance cues and the nAChR-β2 knockouts that have altered activity-dependent refinement of retinocollicular projections. We find that even though the receptive fields are much larger in the ephrin-A knockouts, their On–Off overlap remains unchanged. These neurons also display normal level of selectivity for stimulus direction and orientation. In contrast, the On–Off overlap is disrupted in the β2 knockouts. Together with the previous finding of disrupted direction and orientation selectivity in the β2 knockout mice, our results indicate that molecular guidance cues and activity-dependent processes play different roles in the development of receptive field properties in the SC.
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