Modulation of Emotion Perception via Amygdala Stimulation in Humans.
Modulation of Emotion Perception via Amygdala Stimulation in Humans.
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DOI：
10.3389/fnins.2021.795318
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发表时间：
2021
影响因子：
4.3
通讯作者：
Jobst BC
中科院分区：
文献类型：
--
作者：
Bujarski KA;Song Y;Xie T;Leeds Z;Kolankiewicz SI;Wozniak GH;Guillory S;Aronson JP;Chang L;Jobst BC
多种证据表明，人类杏仁核是神经网络的一部分，对于感知环境刺激的情绪非常重要，包括处理内在吸引力/“善”或厌恶/“坏”，即情感效价。考虑到这一点，我们研究了人类杏仁核的脑电刺激对国际情感图片集（IAPS）中拍摄的图像的情感效价感知的影响。使用癫痫患者的颅内电极，我们首先获得了 8 名患者观看不同情感效价的 IAPS 图像时的事件相关电位 (ERP)。接下来，在另一组 10 名患者（五名女性和五名男性）中，我们测量了 50 Hz 电刺激左侧杏仁核对 IAPS 图像情感效价感知的影响。我们记录了左侧杏仁核的不同 ERP，发现刺激开始后 300-500 毫秒，正价刺激和负价刺激之间的反应 (p = 0.002)，以及中性刺激和负价刺激之间的反应 (p = 0.017) 存在显着差异。接下来，我们发现杏仁核刺激并没有显着影响患者对中性图像的效价的感知（p = 0.58），而刺激诱导患者报告正价（p = 0.05）和负价（< 0.01）图像更中性。这些结果进一步证明左杏仁核参与了感知环境刺激情绪的神经网络。这些发现支持这样的观点：电刺激会破坏这个网络并导致情绪感知的部分破坏。利用这种效应可能对使用深部脑刺激（DBS）和神经调节治疗某些神经精神疾病具有临床意义。
Multiple lines of evidence show that the human amygdala is part of a neural network important for perception of emotion from environmental stimuli, including for processing of intrinsic attractiveness/“goodness” or averseness/“badness,” i.e., affective valence. With this in mind, we investigated the effect of electrical brain stimulation of the human amygdala on perception of affective valence of images taken from the International Affective Picture Set (IAPS). Using intracranial electrodes in patients with epilepsy, we first obtained event-related potentials (ERPs) in eight patients as they viewed IAPS images of varying affective valence. Next, in a further cohort of 10 patients (five female and five male), we measured the effect of 50 Hz electrical stimulation of the left amygdala on perception of affective valence from IAPS images. We recorded distinct ERPs from the left amygdala and found significant differences in the responses between positively and negatively valenced stimuli (p = 0.002), and between neutral and negatively valenced stimuli (p = 0.017) 300–500 ms after stimulus onset. Next, we found that amygdala stimulation did not significantly affect how patients perceived valence for neutral images (p = 0.58), whereas stimulation induced patients to report both positively (p = 0.05) and negatively (< 0.01) valenced images as more neutral. These results render further evidence that the left amygdala participates in a neural network for perception of emotion from environmental stimuli. These findings support the idea that electrical stimulation disrupts this network and leads to partial disruption of perception of emotion. Harnessing this effect may have clinical implications in treatment of certain neuropsychiatric disorders using deep brain stimulation (DBS) and neuromodulation.
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影响因子：
4.3
作者：
Gramfort A;Luessi M;Larson E;Engemann DA;Strohmeier D;Brodbeck C;Goj R;Jas M;Brooks T;Parkkonen L;Hämäläinen M
通讯作者：
Hämäläinen M
影响因子：
5.3
作者：
Dlouhy, Brian J.;Gehlbach, Brian K.;Richerson, George B.
通讯作者：
Richerson, George B.
影响因子：
64.8
作者：
Anderson, AK;Phelps, EA
通讯作者：
Phelps, EA
影响因子：
9.3
作者：
Cuthbert BN;Insel TR
通讯作者：
Insel TR
影响因子：
1.7
作者：
Garavan, H;Pendergrass, JC;Risinger, RC
通讯作者：
Risinger, RC