Spinal neurons innervating multiple local and distant motor pools
Spinal neurons innervating multiple local and distant motor pools
复制标题
脊髓神经元支配多个局部和远端运动池
DOI：
10.1101/2021.06.03.446906
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Ronzano R
中科院分区：
文献类型：
--
作者：
Ronzano R
运动神经元控制肌肉收缩，它们通过前运动回路的募集来产生精确的运动行为。为了了解这些回路如何协调关节之间的运动，有必要了解脊髓神经元是否突触前运动池，投射到一个以上的运动神经元群体。在这里，我们使用修改后的狂犬病病毒在小鼠中追踪调查运动前神经元投射到屈肌或伸肌运动神经元，以及那些投射到拮抗剂对肌肉控制踝关节。我们发现，相似比例的前运动神经元分化为激动剂和拮抗剂运动池。在整个脊髓中可以看到发散的运动前神经元，随着距离后肢增大，数量减少，但比例增加。在颈髓，分歧长下降propriospinal神经元被发现在对侧的第八层，有大的胞体，兴奋性，投射到腰和颈运动神经元，并至少在V0类的一部分。我们的结论是，分布式脊髓运动前神经元协调活动跨多个运动池，并有脊髓神经元介导的拮抗肌的共同收缩。
Motor neurons control muscle contractions, and their recruitment by premotor circuits is tuned to produce accurate motor behaviours. To understand how these circuits coordinate movement across and between joints, it is necessary to understand whether spinal neurons pre-synaptic to motor pools, project to more than one motor neuron population. Here, we used modified rabies virus tracing in mice to investigate premotor INs projecting to synergist flexor or extensor motor neurons, as well as those projecting to antagonist pairs of muscles controlling the ankle joint. We show that similar proportions of premotor neurons diverge to agonist and antagonist motor pools. Divergent premotor neurons were seen throughout the spinal cord, with decreasing numbers but increasing proportion with distance from the hindlimb enlargement. In the cervical cord, divergent long descending propriospinal neurons were found in contralateral lamina VIII, had large somata, were excitatory, projected to both lumbar and cervical motoneurons, and were at least in part of the V0 class. We conclude that distributed spinal premotor neurons coordinate activity across multiple motor pools and that there are spinal neurons mediating co-contraction of antagonist muscles.
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影响因子：
3.3
作者：
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通讯作者：
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影响因子：
9.8
作者：
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DOI：
10.1523/jneurosci.16-03-00974.1996
发表时间：
1996-02
影响因子：
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