Cooperative interactions between hippocampal and striatal systems support flexible navigation.
Cooperative interactions between hippocampal and striatal systems support flexible navigation.
复制标题
海马和纹状体系统之间的合作相互作用支持灵活导航。
DOI：
10.1016/j.neuroimage.2012.01.046
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发表时间：
2012-04-02
期刊：
影响因子：
5.7
通讯作者：
Stern, Chantal E.
中科院分区：
文献类型：
--
作者：
Brown, Thackery I.;Ross, Robert S.;Tobyne, Sean M.;Stern, Chantal E.
对动物和人类的研究表明，海马体对于检索重叠信息序列的不同表示至关重要。最近有证据表明尾状核和眶额皮层也参与重叠空间表征的消歧。海马体和尾状核在功能上是不同的区域，但两者都与眶额皮质有解剖学联系。本研究使用基于功能磁共振成像的人类功能连接分析来检查当参与者使用上下文信息来导航具有共同元素的熟悉的空间路线时海马体、尾状核和眶额皮层之间的功能关系。参与者在扫描仪外接受培训，以第一人称视角浏览虚拟迷宫。重叠的条件迷宫在不同的位置开始和结束，但在中间汇聚，与另一个迷宫共享一些走廊。非重叠条件迷宫不与任何其他迷宫共享任何走廊。成功导航通过重叠的走廊需要识别当前导航路线的上下文信息，以指导对给定试验的适当响应。结果显示，与非重叠迷宫相比，重叠迷宫的海马、尾状核和眶额皮质之间的功能连接性更强。目前的研究结果表明，海马体和尾状核与前额叶结构相互作用，以实现成功的上下文相关导航。
Research in animals and humans has demonstrated that the hippocampus is critical for retrieving distinct representations of overlapping sequences of information. There is recent evidence that the caudate nucleus and orbitofrontal cortex are also involved in disambiguation of overlapping spatial representations. The hippocampus and caudate are functionally distinct regions, but both have anatomical links with the orbitofrontal cortex. The present study used an fMRI-based functional connectivity analysis in humans to examine the functional relationship between the hippocampus, caudate, and orbitofrontal cortex when participants use contextual information to navigate well-learned spatial routes which share common elements. Participants were trained outside the scanner to navigate virtual mazes from a first-person perspective. Overlapping condition mazes began and ended at distinct locations, but converged in the middle to share some hallways with another maze. Non-overlapping condition mazes did not share any hallways with any other maze. Successful navigation through the overlapping hallways required contextual information identifying the current navigational route to guide the appropriate response for a given trial. Results revealed greater functional connectivity between the hippocampus, caudate, and orbitofrontal cortex for overlapping mazes compared to non-overlapping mazes. The current findings suggest that the hippocampus and caudate interact with prefrontal structures cooperatively for successful contextually-dependent navigation.
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影响因子：
16.2
作者：
Fanselow, Michael S.;Dong, Hong-Wei
通讯作者：
Dong, Hong-Wei
影响因子：
5.7
作者：
Boehler, C. N.;Appelbaum, L. G.;Krebs, R. M.;Hopf, J. M.;Woldorff, M. G.
通讯作者：
Woldorff, M. G.
DOI：
10.1523/jneurosci.6021-09.2010
发表时间：
2010-05-26
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Brown TI;Ross RS;Keller JB;Hasselmo ME;Stern CE
通讯作者：
Stern CE
影响因子：
3.5
作者：
Barbas, H;Blatt, GJ
通讯作者：
Blatt, GJ
影响因子：
3.4
作者：
Frey, S;Petrides, M
通讯作者：
Petrides, M