Pinning down response inhibition in the brain--conjunction analyses of the Stop-signal task.
Pinning down response inhibition in the brain--conjunction analyses of the Stop-signal task.
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DOI：
10.1016/j.neuroimage.2010.04.276
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发表时间：
2010-10-01
期刊：
影响因子：
5.7
通讯作者：
Woldorff, M. G.
中科院分区：
文献类型：
--
作者：
Boehler, C. N.;Appelbaum, L. G.;Krebs, R. M.;Hopf, J. M.;Woldorff, M. G.
关键词：
成功的行为需要启动和抑制运动程序的微调相互作用，以有效地应对不断变化的环境需求。研究抑制性运动控制的一个特别有用的范例是停止信号任务，其中已经启动的对Go刺激的反应在随后快速呈现停止刺激时被抑制（产生成功和不成功的停止试验）。尽管这种模式在功能性神经影像学中得到了广泛的应用，但对于使用哪种功能性比较来表征反应抑制相关的大脑活动，还没有达成共识。在这里，我们利用连接分析成功和不成功的停止试验，每个对照参考条件。这种结合方法确定了两种停止试验类型的共同过程，同时排除了特定于任何一种的过程，从而利用了两种情况下存在的一些反应抑制相关活动。使用这种方法从人类受试者的功能磁共振成像数据，我们确定了一个网络的大脑结构，这是连接到两种类型的停止试验，包括外侧下额叶和内侧额叶皮质区和尾状核。此外，与视觉刺激相匹配的参考条件的比较确定了右下顶叶皮层的额外活动，这可能在增强停止刺激的处理中发挥作用。最后，受试者之间停药疗效的差异与左前额叶活动的变化相关。然而，该区域也与一般任务准确性相关（进一步与停止功效直接相关），这表明它实际上可能反映了一种更普遍的性能控制机制，以相对非特异性的方式支持反应抑制。
Successful behavior requires a finely-tuned interplay of initiating and inhibiting motor programs to react effectively to constantly changing environmental demands. One particularly useful paradigm for investigating inhibitory motor control is the Stop-signal task, where already-initiated responses to Go-stimuli are to be inhibited upon the rapid subsequent presentation of a Stop-stimulus (yielding successful and unsuccessful Stop-trials). Despite the extensive use of this paradigm in functional neuroimaging, there is no consensus on which functional comparison to use to characterize response-inhibition-related brain activity. Here, we utilize conjunction analyses of successful and unsuccessful Stop-trials that are each contrasted against a reference condition. This conjunction approach identifies processes common to both Stop-trial types while excluding processes specific to either, thereby capitalizing on the presence of some response-inhibition-related activity in both conditions. Using this approach on fMRI data from human subjects, we identify a network of brain structures that was linked to both types of Stop-trials, including lateral-inferior-frontal and medial-frontal cortical areas and the caudate nucleus. In addition, comparisons with a reference condition matched for visual stimulation identified additional activity in the right inferior parietal cortex that may play a role in enhancing the processing of the Stop-stimuli. Finally, differences in stopping efficacy across subjects were associated with variations in activity in the left anterior insula. However, this region was also associated with general task accuracy (which furthermore correlated directly with stopping efficacy), suggesting that it might actually reflect a more general mechanism of performance control that supports response inhibition in a relatively nonspecific way.
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