Bio-responsive polymer hydrogels homeostatically regulate blood coagulation.
Bio-responsive polymer hydrogels homeostatically regulate blood coagulation.
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DOI：
10.1038/ncomms3168
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发表时间：
2013
影响因子：
16.6
通讯作者：
Werner, Carsten
中科院分区：
文献类型：
--
作者：
Maitz, Manfred F.;Freudenberg, Uwe;Tsurkan, Mikhail V.;Fischer, Marion;Beyrich, Theresa;Werner, Carsten
生物响应性聚合物体系结构可以通过采用类似于生物组织对不同环境约束的动态平衡适应的分子反馈-反应机制来支持医疗治疗。在这里，我们展示了血液凝固响应型水凝胶系统可以提供由环境水平的凝血酶触发的肝素，凝血酶是凝血级联反应的关键酶，而凝血酶反过来又由于肝素的释放而失活。生物响应性水凝胶在存在促凝血剂刺激的情况下，以及在与新鲜的、未抗凝的血液重复孵育期间，在几个小时内定量地熄灭血液凝固。这些特点使引入的材料能够提供可持续的、自动调节的抗凝血，解决了许多医疗疗法的关键挑战。除此之外，探索的概念可能会促进材料的开发，使药物和生物分子能够有效和受控地应用。在合成材料中实施生物分子识别机制可能会使生物医学和相关应用变得丰富。在这里，Maitz等人。提出一种生物响应性水凝胶，其释放抗凝血剂肝素的量与促凝蛋白凝血酶的环境水平成正比。
Bio-responsive polymer architectures can empower medical therapies by engaging molecular feedback-response mechanisms resembling the homeostatic adaptation of living tissues to varying environmental constraints. Here we show that a blood coagulation-responsive hydrogel system can deliver heparin in amounts triggered by the environmental levels of thrombin, the key enzyme of the coagulation cascade, which—in turn—becomes inactivated due to released heparin. The bio-responsive hydrogel quantitatively quenches blood coagulation over several hours in the presence of pro-coagulant stimuli and during repeated incubation with fresh, non-anticoagulated blood. These features enable the introduced material to provide sustainable, autoregulated anticoagulation, addressing a key challenge of many medical therapies. Beyond that, the explored concept may facilitate the development of materials that allow the effective and controlled application of drugs and biomolecules. Implementing biomolecular recognition mechanisms in synthetic materials may enable a wealth of biomedical and related applications. Here Maitz et al. present a bio-responsive hydrogel that releases the anticoagulant heparin in amounts proportional to the environmental levels of the procoagulatory protein thrombin.
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