NICU management and outcomes of infants with trisomy 21 without major anomalies.

NICU management and outcomes of infants with trisomy 21 without major anomalies.
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DOI:
10.1038/s41372-018-0136-5
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发表时间:
2018-08
期刊:
Journal of perinatology : official journal of the California Perinatal Association
影响因子:
--
通讯作者:
Lagatta J
Lagatta J
中科院分区:
其他
文献类型:
--
作者:
McAndrew S;Acharya K;Nghiem-Rao TH;Leuthner S;Clark R;Lagatta J

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描述21三体如何影响新生儿重症监护管理和无先天畸形的足月儿的结局。对2005-2012年间儿科NICU收治的21三体正常足月儿和无异常足月婴儿进行回顾性队列研究。我们比较了诊断、管理、住院时间和出院结果。4,623名21三体婴儿和606,770名非21三体婴儿被确认。在NICU中,有和没有21三体的婴儿中,有三分之一的婴儿是足月的,没有重大异常。21三体婴儿有更多的呼吸窘迫、血小板减少、喂养问题和肺动脉高压。他们接受呼吸支持的时间更长,住院时间也更长。在NICU接受治疗的21三体婴儿中,有三分之一的婴儿是足月的,没有重大异常。常见的诊断和更大的呼吸需求使患有21三体的婴儿面临较长住院时间的风险。
To describe how Trisomy 21 affects neonatal intensive care management and outcomes of full-term infants without congenital anomalies. Retrospective cohort of full term infants without anomalies with and without Trisomy 21 admitted to Pediatrix NICUs from 2005–2012. We compared diagnoses, management, length of stay and discharge outcomes. 4,623 infants with Trisomy 21 and 606,770 infants without Trisomy 21 were identified. One-third of infants in the NICU with and without Trisomy 21 were full term without major anomalies. Trisomy 21 infants had more respiratory distress, thrombocytopenia, feeding problems, and pulmonary hypertension. They received respiratory support for a longer period of time and had a longer length of stay. One-third of infants with Trisomy 21 admitted to the NICU are full term without major anomalies. Common diagnoses and greater respiratory needs place infants with Trisomy 21 at risk for longer length of stay.
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