Indomethacin Attenuates Oxytocin and Hypothalamic‐Pituitary‐Adrenal Axis Responses to Systemic Interleukin‐1β
Indomethacin Attenuates Oxytocin and Hypothalamic‐Pituitary‐Adrenal Axis Responses to Systemic Interleukin‐1β
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吲哚美辛减弱催产素和下丘脑-垂体-肾上腺轴对全身性白细胞介素-1β的反应
作者：
Buller;Xu;Day
Systemic administration of the cytokine IL‐1β produces a significant release of ACTH into the plasma and activation of hypothalamic oxytocin (OT) and corticotropin releasing factor (CRF) cells. However, the mechanism(s) by which systemic IL‐1β induces these responses is not clear. In the present study, we have investigated the proposal that catecholamine cells of the ventrolateral medulla (VLM) and nucleus of the solitary tract (NTS) can relay circulating IL‐1 signals via a prostaglandin‐dependent mechanism to effect the HPA axis responses in the rat. Intra‐arterial administration of IL‐1β (1 pg/kg) to otherwise untreated animals produced a prominent release of ACTH into the plasma, substantial c‐fos expression in paraventricular medial parvocellular (mPVN) corticotropin releasing factor (CRF) cells, supraoptic (SON) and paraventricular nucleus (PVN) OT cells, area postrema cells, NTS and VLM catecholamine cells and cells of the central amygdala. Pretreatment with the prostaglandin synthesis inhibitor, indomethacin (10 mg/kg body weight ia) 15 min before IL‐1β administration (1 pg/kg ia) significantly reduced plasma ACTH release and c‐fos expression in PVN and SON OT cells and MPVN CRF cells. In addition, the area postrema, A1 and C1 catecholamine cell groups of the VLM and A2 and C2 catecholamine cell groups of the NTS, all exhibited concomitant reductions in c‐fos expression. Conversely indomethacin administration did not alter the IL1β‐induced expression of c‐fos in the central amygdala. These data suggest that central pathways involved in the IL‐1β‐induced activation of the HPA axis and OT cells are, at least in part, dependent upon prostaglandin synthesis. It is proposed that neurons in the area postrema, NTS and VLM might mediate this IL‐1β‐induced activation of hypothalamic CRF and OT cells and release of ACTH into the plasma.
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大鼠脑室内注射重组人白细胞介素-1 诱导促肾上腺皮质激素释放：前列腺素可能参与。
影响因子：
4.8
作者：
Katsuura,G;Gottschall,PE;Dahl,RR;Arimura,A
通讯作者：
Arimura,A
影响因子：
56.9
作者：
SAPOLSKY, R;RIVIER, C;VALE, W
通讯作者：
VALE, W
下丘脑的去甲肾上腺素能神经支配参与肾上腺皮质对白介素-1 的反应。
影响因子：
4.1
作者：
Chuluyan,HE;Saphier,D;Rohn,WM;Dunn,AJ
通讯作者：
Dunn,AJ
影响因子：
4.1
作者：
GRAY, TS;CARNEY, ME;MAGNUSON, DJ
通讯作者：
MAGNUSON, DJ
Interleukin-1 通过间接作用刺激 ACTH 释放，这需要内源性促肾上腺皮质激素释放因子。
影响因子：
4.8
作者：
Uehara,A;Gottschall,PE;Dahl,RR;Arimura,A
通讯作者：
Arimura,A