Age of first exposure to tackle football and chronic traumatic encephalopathy.
Age of first exposure to tackle football and chronic traumatic encephalopathy.
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DOI：
10.1002/ana.25245
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发表时间：
2018-05
影响因子：
11.2
通讯作者：
McKee AC
中科院分区：
文献类型：
--
作者：
Alosco ML;Mez J;Tripodis Y;Kiernan PT;Abdolmohammadi B;Murphy L;Kowall NW;Stein TD;Huber BR;Goldstein LE;Cantu RC;Katz DI;Chaisson CE;Martin B;Solomon TM;McClean MD;Daneshvar DH;Nowinski CJ;Stern RA;McKee AC
探讨首次接触铲球的年龄对经神经病理证实的铲球运动员的CTE病理严重程度和神经行为症状起病年龄的影响。样本包括246名铲球运动员，他们捐赠了自己的大脑进行神经病理检查。诊断为CTE 211例(126/211例，无合并神经退行性疾病)，非CTE 35例。线人面谈确定了首次接触的年龄以及认知和行为/情绪症状的开始年龄。分析考虑了比赛的十年和持续时间。接触年龄与CTE病理严重程度、阿尔茨海默病或路易小体病理无关。在患有慢性阻塞性肺病的211名参与者中，每一年开始踢铲球比赛的年轻参与者预计认知症状出现的时间要早2.44年(p<；0.0001)，行为/情绪症状的出现时间要早2.50年(p<；0.0001)。12岁之前的暴露年龄预测认知(p<；0.0001)和行为/情绪(p<；0.0001)症状出现的时间分别提前13.39年和13.28年。在痴呆症参与者中，较年轻的暴露年龄对应较早的功能障碍发作。在126名仅接受CTE的参与者中也观察到了类似的效果。在没有CTE的参与者中，效果大小是相似的。在这个已故铲球运动员的样本中，接触铲球的年龄较小与CTE病理严重程度无关，但预示着神经行为症状出现得更早。年轻人接触足球可能会降低他们对晚年神经病理的适应能力。这些发现可能不会推广到更广泛的铲球人群，而线人报告可能影响了估计影响的准确性。
To examine the effect of age of first exposure to tackle football on CTE pathological severity and age of neurobehavioral symptom onset in tackle football players with neuropathologically-confirmed CTE. The sample included 246 tackle football players who donated their brains for neuropathological examination. 211 were diagnosed with CTE (126/211 were without comorbid neurodegenerative diseases) and 35 were without CTE. Informant interviews ascertained age of first exposure and age of cognitive and behavioral/mood symptom onset. Analyses accounted for decade and duration of play. Age of exposure was not associated with CTE pathological severity, or Alzheimer’s disease or Lewy body pathology. In the 211 participants with CTE, every one year younger participants began to play tackle football predicted earlier reported cognitive symptom onset by 2.44 years (p<0.0001) and behavioral/mood symptoms by 2.50 years (p<0.0001). Age of exposure before 12 predicted earlier cognitive (p<0.0001) and behavioral/mood (p<0.0001) symptom onset by 13.39 and 13.28 years, respectively. In participants with dementia, younger age of exposure corresponded to earlier functional impairment onset. Similar effects were observed in the 126 CTE only participants. Effect sizes were comparable in participants without CTE. In this sample of deceased tackle football players, younger age of exposure to tackle football was not associated with CTE pathological severity, but predicted earlier neurobehavioral symptom onset. Youth exposure to tackle football may reduce resiliency to late life neuropathology. These findings may not generalize to the broader tackle football population and informant-report may have affected the accuracy of the estimated effects.
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影响因子：
2.5
作者：
Gogtay, Nitin;Thompson, Paul M.
通讯作者：
Thompson, Paul M.
DOI：
10.1186/s13195-014-0068-z
发表时间：
2014
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Montenigro PH;Baugh CM;Daneshvar DH;Mez J;Budson AE;Au R;Katz DI;Cantu RC;Stern RA
通讯作者：
Stern RA
影响因子：
29
作者：
Deshpande, Sameer K.;Hasegawa, Raiden B.;Small, Dylan S.
通讯作者：
Small, Dylan S.
影响因子：
1.7
作者：
Klingberg, T;Vaidya, CJ;Hedehus, M
通讯作者：
Hedehus, M
影响因子：
3.7
作者：
Angrist, JD;Imbens, GW;Rubin, DB
通讯作者：
Rubin, DB