Selective and self-guided micro-ablation of tissue with plasmonic nanobubbles.
Selective and self-guided micro-ablation of tissue with plasmonic nanobubbles.
复制标题
DOI：
10.1016/j.jss.2010.10.039
复制
发表时间：
2011-03
期刊：
影响因子：
--
通讯作者：
Lapotko DO
中科院分区：
文献类型：
--
作者：
Lukianova-Hleb EY;Koneva II;Oginsky AO;La Francesca S;Lapotko DO
用于组织消除的手术和激光方法的准确性、选择性和安全性通常在微观尺度上受到限制。我们开发了一种新的代理，等离子体纳米气泡（PNB），用于以微米精度光学引导选择性消除靶组织。在两种不同的浅表肿瘤和血管斑块模型中对PNB进行体外测试。用短激光脉冲在金纳米颗粒（递送到靶组织）周围选择性地产生PNB。单层的癌细胞和动脉粥样硬化斑块组织被消除与微米精度的PNB和没有热和机械损伤侧支正常组织。通过激光脉冲（532 nm，持续时间0.5和10 ns）的能量密度来动态控制PNB的效果，并且通过PNB的光学散射来引导PNB的效果。等离子体纳米气泡显示出在微观水平上提供精确的、可调的、选择性的和引导的组织消融，并且可以用作新一代的外科手术工具。
The accuracy, selectivity and safety of surgical and laser methods for tissue elimination are often limited at microscale. We developed a novel agent, the plasmonic nanobubble (PNB), for optically guided selective elimination of the target tissue with micrometer precision. PNBs were tested in vitro in the two different models of superficial tumors and vascular plaques. PNBs were selectively generated around gold nanoparticles (delivered to the target tissues) with short laser pulses. Monolayers of cancerous cells and atherosclerotic plaque tissue were eliminated with PNBs with micrometer accuracy and without thermal and mechanical damage to collateral normal tissues. The effect of the PNB was dynamically controlled through the fluence of laser pulses (532 nm, duration 0.5 and 10 ns) and was guided through the optical scattering by PNB. plasmonic nanobubbles were shown to provide precise, tunable, selective and guided ablation of tissue at a microcscopic level and could be employed as a new generation of surgical tools.
登录
查看更多内容
DOI：
10.1007/s10840-007-9184-z
发表时间：
2008-01
影响因子：
1.8
作者：
Kanagaratnam, Prapa;Koa-Wing, Michael;Wallace, Daniel T.;Goldenberg, Alex S.;Peters, Nicholas S.;Davies, D. Wyn
通讯作者：
Davies, D. Wyn
DOI：
10.2217/nnm.09.59
发表时间：
2009-10
期刊：
Nanomedicine (London, England)
影响因子：
--
作者：
Lapotko D
通讯作者：
Lapotko D
影响因子：
10.8
作者：
Anderson, Lindsey J. E.;Hansen, Eric;Lukianova-Hleb, Ekaterina Y.;Hafner, Jason H.;Lapotko, Dmitri O.
通讯作者：
Lapotko, Dmitri O.
影响因子：
78.5
作者：
Kennedy, JE
通讯作者：
Kennedy, JE
影响因子：
5.5
作者：
Lapotko, Dmitri O.;Lukianova-Hleb, Ekaterina Y.;Oraevsky, Alexander A.
通讯作者：
Oraevsky, Alexander A.