Effect of Hydrophobic Polypeptide Length on Performances of Thermo-Sensitive Hydrogels.
Effect of Hydrophobic Polypeptide Length on Performances of Thermo-Sensitive Hydrogels.
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DOI：
10.3390/molecules23051017
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发表时间：
2018-04-26
期刊：
影响因子：
--
通讯作者：
Feng X
中科院分区：
文献类型：
--
作者：
Han J;Zhao X;Xu W;Wang W;Han Y;Feng X
热敏凝胶由于其加工方便、易于功能化等特点，在医学领域被广泛用作药物载体。然而，由于其生物相容性和生物降解性不理想，严重影响了其整体性能。为此，我们采用开环聚合的方法合成了不同聚合度的聚l-丙氨酸（PLAla）基热敏水凝胶。得到的mPEG45−PLAla共聚物具有明显的转变温度和降解能力。发现疏水侧基长度的微小变化对多肽水凝胶的凝胶化行为有决定性的影响。在相同浓度下，疏水端越长，凝胶的凝胶温度越低，凝胶性能越好。水凝胶凝胶化速度快，生物相容性强，可降解性好。因此，这种热敏水凝胶是一种很有前景的生物医学材料。
Thermosensitive gels are commonly used as drug carriers in medical fields, mainly due to their convenient processing and easy functionalization. However, their overall performance has been severely affected by their unsatisfying biocompatibility and biodegradability. To this end, we synthesized poly(l-alanine) (PLAla)-based thermosensitive hydrogels with different degrees of polymerization by ring-opening polymerization. The obtained mPEG45−PLAla copolymers showed distinct transition temperatures and degradation abilities. It was found that slight changes in the length of hydrophobic side groups had a decisive effect on the gelation behavior of the polypeptide hydrogel. Longer hydrophobic ends led to a lower gelation temperature of gel at the same concentration, which implied better gelation capability. The hydrogels showed rapid gelling, enhanced biocompatibility, and better degradability. Therefore, this thermosensitive hydrogel is a promising material for biomedical application.
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影响因子：
3.8
作者：
Tibbitt, Mark W.;Anseth, Kristi S.
通讯作者：
Anseth, Kristi S.
DOI：
10.1002/jbm.a.36186
发表时间：
2017-12
期刊：
Journal of biomedical materials research. Part A
影响因子：
--
作者：
Shahriari D;Shibayama M;Lynam DA;Wolf KJ;Kubota G;Koffler JY;Tuszynski MH;Campana WM;Sakamoto JS
通讯作者：
Sakamoto JS
影响因子：
10
作者：
Ansari S;Diniz IM;Chen C;Sarrion P;Tamayol A;Wu BM;Moshaverinia A
通讯作者：
Moshaverinia A
影响因子：
41.2
作者：
Conde J;Oliva N;Atilano M;Song HS;Artzi N
通讯作者：
Artzi N
影响因子：
2.4
作者：
Knight E;Przyborski S
通讯作者：
Przyborski S