Pyramidal cells in V1 of African rodents are bigger, more branched and more spiny than those in primates.
Pyramidal cells in V1 of African rodents are bigger, more branched and more spiny than those in primates.
复制标题
DOI：
10.3389/fnana.2014.00004
复制
发表时间：
2014
影响因子：
2.9
通讯作者：
Manger P
中科院分区：
文献类型：
--
作者：
Elston GN;Manger P
锥体细胞的特征是在皮层套上有明显不同大小的树突树、分支模式和棘密度。此外，锥体细胞已被证明在不同物种的同源皮质区之间的结构不同;然而，大多数这些研究已经在灵长类动物中进行。虽然锥体细胞已被量化在一些其他物种的一些皮质区，但至今还没有统一的比较数据，锥体细胞结构在一个同源的皮质区之间的物种在不同的目的。在这里，我们研究了第三层锥体细胞V1的三种啮齿动物，大甘蔗大鼠，高原沙鼠，和四条纹小鼠，由相同的方法用于采样数据从第三层锥体细胞在灵长类动物。这些数据揭示了啮齿动物和灵长类动物之间明显不同的趋势：在啮齿动物大脑中，随着V1大小的增加，锥体细胞树突树中的棘的大小、分支复杂性和数量明显增加，而灵长类动物中的差异相对较小。此外，啮齿类动物的锥体细胞比灵长类动物的锥体细胞更大，分支更多，棘状突起更多。例如，成年猕猴V1区锥体细胞的树突树比成年猕猴的V1区锥体细胞的树突树大近3倍，基底树突树的棘数是成年猕猴的10倍以上（分别为7900和600），而成年猕猴的V1区锥体细胞的棘数是成年猕猴的40倍。这些差异在多大程度上是由发育造成的，或反映了进化和/或加工的专门化，仍有待确定。
Pyramidal cells are characterized by markedly different sized dendritic trees, branching patterns, and spine density across the cortical mantle. Moreover, pyramidal cells have been shown to differ in structure among homologous cortical areas in different species; however, most of these studies have been conducted in primates. Whilst pyramidal cells have been quantified in a few cortical areas in some other species there are, as yet, no uniform comparative data on pyramidal cell structure in a homologous cortical area among species in different Orders. Here we studied layer III pyramidal cells in V1 of three species of rodents, the greater cane rat, highveld gerbil, and four-striped mouse, by the same methodology used to sample data from layer III pyramidal cells in primates. The data reveal markedly different trends between rodents and primates: there is an appreciable increase in the size, branching complexity, and number of spines in the dendritic trees of pyramidal cells with increasing size of V1 in the brain in rodents, whereas there is relatively little difference in primates. Moreover, pyramidal cells in rodents are larger, more branched and more spinous than those in primates. For example, the dendritic trees of pyramidal cells in V1 of the adult cane rat are nearly three times larger, and have more than 10 times the number of spines in their basal dendritic trees, than those in V1 of the adult macaque (7900 and 600, respectively), which has a V1 40 times the size that of the cane rat. It remains to be determined to what extent these differences may result from development or reflect evolutionary and/or processing specializations.
登录
查看更多内容
DOI：
10.1523/jneurosci.2581-12.2012
发表时间：
2012-10-03
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Amatrudo JM;Weaver CM;Crimins JL;Hof PR;Rosene DL;Luebke JI
通讯作者：
Luebke JI
DOI：
10.1023/a:1024134312173
发表时间：
2002-03-01
期刊：
JOURNAL OF NEUROCYTOLOGY
影响因子：
--
作者：
Benavides-Piccione, R;Ballesteros-Yáñez, I;Yuste, R
通讯作者：
Yuste, R
影响因子：
1.7
作者：
Elston, GN;Elston, A;Casagrande, V
通讯作者：
Casagrande, V
DOI：
10.1073/pnas.1010356107
发表时间：
2010-09-07
影响因子：
11.1
作者：
Collins, Christine E.;Airey, David C.;Kaas, Jon H.
通讯作者：
Kaas, Jon H.
影响因子：
3.3
作者：
Ballesteros-Yáñez, I;Benavides-Piccione, R;DeFelipe, J
通讯作者：
DeFelipe, J