Urinary biomarkers of exposure to jet fuel (JP-8).

Urinary biomarkers of exposure to jet fuel (JP-8).
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DOI:
10.1289/ehp.6275
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发表时间:
2003-11
影响因子:
10.4
通讯作者:
Rappaport SM
Rappaport SM
中科院分区:
环境科学与生态学1区
文献类型:
--
作者:
Serdar B;Egeghy PP;Waidyanatha S;Gibson R;Rappaport SM

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对来自322名美国空军人员的尿样中的苯、萘、1-和2-萘酚进行了测量,这些人事先被归类为可能有低、中或高暴露于喷气燃料[喷气推进燃料-8(JP-8)]。在暴露后样本中,高暴露组的这些分析物水平比低暴露组高3-29倍,比中等暴露组高2-12倍。与吸烟相比,大量接触JP-8所产生的苯的数量大致相同,而产生的萘的数量是前者的三倍多。暴露后尿液中以萘为基础的生物标记物以及空气和呼吸中的萘之间存在很强的相关性。我们的结论是,尿萘和萘酚可以作为航空燃油暴露的生物标志物。在这些化合物中,萘酚可能更有用,因为它们的丰度更高,消除动力学更慢。
Benzene, naphthalene, and 1- and 2-naphthol were measured in urine samples obtained from 322 U.S. Air Force personnel categorized a priori as likely to have low, moderate, or high exposure to jet fuel [jet propulsion fuel-8 (JP-8)]. In postexposure samples, levels of these analytes in the high-exposure group were 3- to 29-fold greater than in the low-exposure group and 2- to 12-fold greater than in the moderate-exposure group. Heavy exposure to JP-8 contributed roughly the same amount of benzene and more than three times the amount of naphthalene compared with cigarette smoking. Strong correlations were observed among postexposure levels of naphthalene-based biomarkers in urine and naphthalene in air and breath. We conclude that urinary naphthalene and the naphthols can serve as biomarkers of exposure to jet fuel. Of these, the naphthols are probably more useful because of their greater abundance and slower elimination kinetics.
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