An automated room disinfection system using ozone is highly active against surrogates for SARS-CoV-2.
An automated room disinfection system using ozone is highly active against surrogates for SARS-CoV-2.
复制标题
使用臭氧的自动化房间消毒系统对SARS-CoV-2的替代物具有高度活性。
DOI：
10.1016/j.jhin.2021.04.007
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Knobloch JK
中科院分区：
文献类型：
--
作者：
Franke G;Knobling B;Brill FH;Becker B;Klupp EM;Belmar Campos C;Pfefferle S;Lütgehetmann M;Knobloch JK
患者环境表面上存在的冠状病毒是间接传播的潜在来源。人工清洁和消毒措施并不总能充分去除表面污染。这增加了自动化解决方案在医院环境中对房间进行最终消毒的重要性。臭氧是一种高效的消毒剂，与高湿度相结合，是对抗呼吸道病毒的有效剂。目前的设备允许连续雾化高房间湿度以及臭氧生产没有任何消耗品。在接下来的研究中，基于臭氧的全自动房间净化系统对噬菌体Φ6 （phi 6）和牛冠状病毒L9的有效性进行了测试，这两种病毒是大流行冠状病毒SARS-CoV-2的替代病毒。为此，用替代病毒污染了各种表面（瓷砖、不锈钢表面和家具板），并将其置于气密试验室的两个不同级别。根据制造商的说明使用自动去污装置后，从表面回收替代病毒并进行定量培养检查。然后，计算折减系数。基于臭氧的室内去污装置在不同表面和位置的情况下，对这两种替代生物都达到了抗病毒效果（降低系数bbbb4 log10），证实在使用条件下具有高活性。臭氧对SARS-CoV-2替代生物具有高度活性。进一步的研究是必要的安全应用和有效性的实践，并纳入日常过程。
The presence of coronaviruses on surfaces in the patient environment is a potential source of indirect transmission. Manual cleaning and disinfection measures do not always achieve sufficient removal of surface contamination. This increases the importance of automated solutions in the context of final disinfection of rooms in the hospital setting. Ozone is a highly effective disinfectant which, combined with high humidity, is an effective agent against respiratory viruses. Current devices allow continuous nebulization for high room humidity as well as ozone production without any consumables. In the following study, the effectiveness of a fully automatic room decontamination system based on ozone was tested against bacteriophage Φ6 (phi 6) and bovine coronavirus L9, as surrogate viruses for the pandemic coronavirus SARS-CoV-2. For this purpose, various surfaces (ceramic tile, stainless steel surface and furniture board) were soiled with the surrogate viruses and placed at two different levels in a gas-tight test room. After using the automatic decontamination device according to the manufacturer's instructions, the surrogate viruses were recovered from the surfaces and examined by quantitative cultures. Then, reduction factors were calculated. The ozone-based room decontamination device achieved virucidal efficacy (reduction factor >4 log10) against both surrogate organisms regardless of the different surfaces and positions confirming a high activity under the used conditions. Ozone is highly active against SARS-CoV-2 surrogate organisms. Further investigations are necessary for a safe application and efficacy in practice as well as integration into routine processes.
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