Can ozone inactivate SARS-CoV-2? A review of mechanisms and performance on viruses.
Can ozone inactivate SARS-CoV-2? A review of mechanisms and performance on viruses.
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DOI：
10.1016/j.jhazmat.2021.125658
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发表时间：
2021-08-05
影响因子：
13.6
通讯作者：
Sans C
中科院分区：
文献类型：
--
作者：
Bayarri B;Cruz-Alcalde A;López-Vinent N;Micó MM;Sans C
严重急性呼吸综合征冠状病毒-2 (SARS-CoV-2) 大流行给全球社会带来了挑战。基于臭氧（一种强氧化剂）的技术已被评估可以灭活气溶胶和污染物中的这种病毒。然而，数据的高度多样性阻碍了建立共同基础来确定使用这些技术的最佳实践的可能性。此外，对于臭氧病毒灭活的主要机制还缺乏共识。这篇评论审查了有关气相臭氧应用以灭活不同病毒的最相关信息（包括最近有关 SARS-CoV-2 的出版物），并指出包膜改变是包膜病毒的主要反应途径，例如 SARS-CoV-2 的情况。还可以得出结论，气态臭氧确实可以作为一种有效的消毒剂，成功地灭活气溶胶或污染物中的病毒，例如甲型 H1N1 流感、MERS-CoV、SARS-CoV-1 甚至 SARS-CoV-2。在审查的研究中，低臭氧暴露量（仅约 0.1–0.4 mg L-1 分钟）即可实现气溶胶约 4 log10 的灭活，而可能需要 1 至 4 mg L-1 分钟的暴露量才能保证不同污染物的 3–4 log10 灭活。尽管还需要进一步研究，但臭氧是对抗表面和室内场所的 SARS-CoV-2 或其他病毒的有效候选者。
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has challenged societies around the globe. Technologies based on ozone, a powerful oxidant, have been evaluated to inactivate this virus in aerosols and fomites. However, the high data diversity hinders the possibility of establishing a common ground for determining best practices for the use of these technologies. Furthermore, there is a lack of consensus regarding which are the main mechanisms of ozone virus inactivation. This critical review examined the most relevant information available regarding ozone application in gas-phase for different viruses inactivation (including recent publications dealing with SARS-CoV-2), and pointed towards envelope alteration as the main reaction pathway for enveloped viruses, such as is the case of SARS-CoV-2. It could also be concluded that gaseous ozone can be indeed an effective disinfectant, successfully inactivating viruses such us influenza A H1N1, MERS-CoV, SARS-CoV-1 or even SARS-CoV-2 in aerosols or fomites. In reviewed works, low ozone exposures, just around 0.1–0.4 mg L-1 min, achieve about 4 log10 of inactivation in aerosols, while exposures between 1 and 4 mg L-1 min may be needed to guarantee an inactivation of 3–4 log10 in different fomites. Although further studies are required, ozone is an effective candidate to be used against SARS-CoV-2 or other viruses in surfaces and indoor locations.
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