Seroprevalence following the second wave of Pandemic 2009 H1N1 influenza in Pittsburgh, PA, USA.
Seroprevalence following the second wave of Pandemic 2009 H1N1 influenza in Pittsburgh, PA, USA.
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DOI：
10.1371/journal.pone.0011601
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发表时间：
2010-07-14
期刊：
影响因子：
3.7
通讯作者：
Ross TM
中科院分区：
文献类型：
--
作者：
Zimmer SM;Crevar CJ;Carter DM;Stark JH;Giles BM;Zimmerman RK;Ostroff SM;Lee BY;Burke DS;Ross TM
2009年4月，一种新的大流行流感毒株感染了墨西哥和美国数千人，并在全世界迅速传播。在接下来的夏季，北半球的病例有所减少，而南半球则经历了以新毒株为主的典型流感季节。秋季，第二波 H1N1 流感席卷美国，10 月中旬在该国大部分地区达到顶峰，12 月初恢复到基线水平。目的是确定匹兹堡地区居民出生十年前针对 2009 年 H1N1 流感大流行的抗体的血清流行率。匿名血样从临床实验室获得，并按 1920 年至 2009 年的出生十年进行分类。使用血凝抑制试验，每十年从 2009 年 11 月中旬和 12 月初从医院和诊所患者身上抽取的血液样本中检测了大约 100 个样本 (n = 846)。测量了针对大流行 H1N1 (A/California/7/2009) 的年龄特异性血清阳性率，并将其与先前在人群中传播的 H1N1 毒株的血清阳性率进行了比较。 2007 年、1957 年和 1918 年。（A/布里斯班/59/2007、A/丹佛/1/1957 和 A/南卡罗来纳/1/1918）。 2008 年健康年轻人储存的血清样本被用作对照组 (n = 100)。 2009 年 H1N1 流感大流行的血清阳性率因年龄组而异，其中 10-19 岁儿童的血清阳性率最高（45%），70-79 岁人群的血清阳性率最低（5%）。 18-24 岁对照样本中的基线血清阳性率为 6%。所有年龄段的 H1N1 流感总体血清阳性率约为 21%。 2009 年第二波 H1N1 流感高峰后，HAI 血清阳性率结果表明，匹兹堡地区 21% 的人已被感染并产生了免疫力。外推到整个美国人口，我们估计 2009 年至少有 6300 万人被感染。正如在临床病例中观察到的那样，这项血清流行病学研究显示学龄儿童的感染率最高。
In April 2009, a new pandemic strain of influenza infected thousands of persons in Mexico and the United States and spread rapidly worldwide. During the ensuing summer months, cases ebbed in the Northern Hemisphere while the Southern Hemisphere experienced a typical influenza season dominated by the novel strain. In the fall, a second wave of pandemic H1N1 swept through the United States, peaking in most parts of the country by mid October and returning to baseline levels by early December. The objective was to determine the seroprevalence of antibodies against the pandemic 2009 H1N1 influenza strain by decade of birth among Pittsburgh-area residents. Anonymous blood samples were obtained from clinical laboratories and categorized by decade of birth from 1920–2009. Using hemagglutination-inhibition assays, approximately 100 samples per decade (n = 846) were tested from blood samples drawn on hospital and clinic patients in mid-November and early December 2009. Age specific seroprevalences against pandemic H1N1 (A/California/7/2009) were measured and compared to seroprevalences against H1N1 strains that had previously circulated in the population in 2007, 1957, and 1918. (A/Brisbane/59/2007, A/Denver/1/1957, and A/South Carolina/1/1918). Stored serum samples from healthy, young adults from 2008 were used as a control group (n = 100). Seroprevalences against pandemic 2009 H1N1 influenza varied by age group, with children age 10–19 years having the highest seroprevalence (45%), and persons age 70–79 years having the lowest (5%). The baseline seroprevalence among control samples from 18–24 year-olds was 6%. Overall seroprevalence against pandemic H1N1 across all age groups was approximately 21%. After the peak of the second wave of 2009 H1N1, HAI seroprevalence results suggest that 21% of persons in the Pittsburgh area had become infected and developed immunity. Extrapolating to the entire US population, we estimate that at least 63 million persons became infected in 2009. As was observed among clinical cases, this sero-epidemiological study revealed highest infection rates among school-age children.
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影响因子：
3.7
作者：
Bright RA;Carter DM;Crevar CJ;Toapanta FR;Steckbeck JD;Cole KS;Kumar NM;Pushko P;Smith G;Tumpey TM;Ross TM
通讯作者：
Ross TM
影响因子：
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作者：
Dereeper A;Guignon V;Blanc G;Audic S;Buffet S;Chevenet F;Dufayard JF;Guindon S;Lefort V;Lescot M;Claverie JM;Gascuel O
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Gascuel O
影响因子：
15.3
作者：
Shope, RE
通讯作者：
Shope, RE
影响因子：
11.8
作者：
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通讯作者：
Kilbourne ED
与传染病的传播相关的社会接触和混合模式。
影响因子：
15.8
作者：
Mossong, Joeel;Hens, Niel;Jit, Mark;Beutels, Philippe;Auranen, Kari;Mikolajczyk, Rafael;Massari, Marco;Salmaso, Stefania;Tomba, Gianpaolo Scalia;Wallinga, Jacco;Heijne, Janneke;Sadkowska-Todys, Malgorzata;Rosinska, Magdalena;Edmunds, W. John
通讯作者：
Edmunds, W. John