Race disparities in pubertal timing: Implications for cardiovascular disease risk among African American women.
Race disparities in pubertal timing: Implications for cardiovascular disease risk among African American women.
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DOI：
10.1007/s11113-017-9441-5
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发表时间：
2017-10
影响因子：
2.4
通讯作者：
Benner AD
中科院分区：
文献类型：
--
作者：
Bleil ME;Booth-LaForce C;Benner AD
与白色女孩相比，非洲裔美国女孩的性成熟加快，这是通过青春期发育指标来衡量的，包括第一次月经的年龄。越来越多的流行病学证据表明，青春期发育的时间可能对青春期和成年期的心脏代谢健康有很大的影响。事实上，年轻的初潮年龄与心血管风险因素特征较差、这些特征随时间推移而恶化以及心血管事件风险增加（包括非致命性心血管疾病事件和心血管特异性和全因死亡率）相关。然而，由于这一文献几乎仅限于白色女孩/妇女，这种同样的关联是否存在于非裔美国女孩/妇女中尚未澄清。在目前的叙述性综述中，讨论了非洲裔美国女孩经历青春期提前的成熟脆弱性，以及文献中检查青春期提前时间及其前因的健康结果的结果，包括非洲裔美国女孩经常经历的不成比例的早期生活逆境暴露。在这些文献中的差距突出，特别是在少数民族女孩/妇女的研究缺乏方面，并提出了一个概念框架，表明非洲裔美国人和白色女孩之间的青春期时间的差异可能部分促成非洲裔美国人和白色妇女之间的心脏代谢疾病的成年风险的既定差异。这些领域的未来研究可能会指出新的干预领域，以预防或减少非洲裔美国妇女的心脏代谢风险增加，这是一个重要的公共卫生目标。
Compared to white girls, sexual maturation is accelerated in African American girls as measured by indicators of pubertal development, including age at first menses. Increasing epidemiological evidence suggests that the timing of pubertal development may have strong implications for cardio-metabolic health in adolescence and adulthood. In fact, younger menarcheal age has been related prospectively to poorer cardiovascular risk factor profiles, a worsening of these profiles over time, and an increase in risk for cardiovascular events, including non-fatal incident cardiovascular disease and cardiovascular-specific and all-cause mortality. Yet, because this literature has been limited almost exclusively to white girls/women, whether this same association is present among African American girls/women has not been clarified. In the current narrative review, the well-established vulnerability of African American girls to experience earlier pubertal onset is discussed as are findings from literatures examining the health outcomes of earlier pubertal timing and its antecedents, including early life adversity exposures often experienced disproportionately in African American girls. Gaps in these literatures are highlighted especially with respect to the paucity of research among minority girls/women, and a conceptual framework is posited suggesting disparities in pubertal timing between African American and white girls may partially contribute to well-established disparities in adulthood risk for cardio-metabolic disease between African American and white women. Future research in these areas may point to novel areas for intervention in preventing or lessening the heightened cardio-metabolic risk among African American women, an important public health objective.
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影响因子：
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