Chronic ethanol intake alters circadian phase shifting and free-running period in mice.
Chronic ethanol intake alters circadian phase shifting and free-running period in mice.
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DOI：
10.1177/0748730409338449
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发表时间：
2009-08
影响因子：
3.5
通讯作者：
Rosenwasser AM
中科院分区：
文献类型：
--
作者：
Seggio JA;Fixaris MC;Reed JD;Logan RW;Rosenwasser AM
在人类酗酒者和实验动物中，慢性酒精摄入与睡眠和昼夜节律的广泛中断有关。最近的研究表明，慢性和急性乙醇治疗改变了大鼠和仓鼠的昼夜节律起搏器的基本特性，包括自由运行期和对光和非光相移刺激的反应。在目前的工作中，作者将这些观察结果扩展到C57BL/6J小鼠，这是一种自交品系，其特点是非常高水平的自愿乙醇摄入和可靠稳定的自由运行的昼夜活动节律。小鼠被单独安置在跑轮笼中，在自愿或强制摄入乙醇的条件下，而对照组则保持在白开水中。在恒定的黑暗条件下，强制摄入乙醇显著减弱了光相延迟（但没有减弱光相提前）和缩短了自由运行期，但自愿摄入乙醇对这两个参数都没有影响。因此，在C57BL/6J小鼠中，需要高水平的慢性乙醇摄入来改变基本的昼夜节律起搏器特性，而不是在自愿饮酒条件下正常达到的水平。这些观察结果可能与该菌株在其他几个表型域显示的相对乙醇不敏感有关，包括乙醇诱导的镇静、共济失调和戒断。另外的实验将研究对乙醇的时间生物学敏感性在一系列自交系显示不同的乙醇相关表型。
Chronic alcohol intake is associated with widespread disruptions in sleep and circadian rhythms in both human alcoholics and in experimental animals. Recent studies have demonstrated that chronic and acute ethanol treatments alter fundamental properties of the circadian pacemaker—including free-running period and responsiveness to photic and nonphotic phase-shifting stimuli—in rats and hamsters. In the present work, the authors extend these observations to the C57BL/6J mouse, an inbred strain characterized by very high levels of voluntary ethanol intake and by reliable and stable free-running circadian activity rhythms. Mice were housed individually in running-wheel cages under conditions of either voluntary or forced ethanol intake, whereas controls were maintained on plain water. Forced ethanol intake significantly attenuated photic phase delays (but not phase advances) and shortened free-running period in constant darkness, but voluntary ethanol intake failed to affect either of these parameters. Thus, high levels of chronic ethanol intake, beyond those normally achieved under voluntary drinking conditions, are required to alter fundamental circadian pacemaker properties in C57BL/6J mice. These observations may be related to the relative ethanol insensitivity displayed by this strain in several other phenotypic domains, including ethanol-induced sedation, ataxia, and withdrawal. Additional experiments will investigate chronobiological sensitivity to ethanol in a range of inbred strains showing diverse ethanol-related phenotypes.
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影响因子：
10.6
作者：
Kühlwein, E;Hauger, RL;Irwin, MR
通讯作者：
Irwin, MR
影响因子：
2.8
作者：
Mrosovsky, N
通讯作者：
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作者：
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DOI：
10.1111/j.1530-0277.2006.00248.x
发表时间：
2006-12-01
影响因子：
3.2
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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