Urinary metabolites of di(2-ethylhexyl) phthalate are associated with decreased steroid hormone levels in adult men.
Urinary metabolites of di(2-ethylhexyl) phthalate are associated with decreased steroid hormone levels in adult men.
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DOI：
10.2164/jandrol.108.006403
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发表时间：
2009-05
影响因子：
--
通讯作者：
Hauser R
中科院分区：
文献类型：
--
作者：
Meeker JD;Calafat AM;Hauser R
实验动物研究表明，暴露于某些邻苯二甲酸酯可能与内分泌功能改变以及对男性生殖发育和功能的不良影响有关，但人体研究有限。在本研究中，尿液和血清样本收集了425名男性通过美国不孕症诊所招募。测量了邻苯二甲酸二（2-乙基己基）酯（DEHP）的水解代谢产物邻苯二甲酸单（2-乙基己基）酯（MEHP）和其他邻苯二甲酸单酯代谢产物的尿液浓度，沿着睾酮、雌二醇、SHBG、FSH、LH、雌二醇B和催乳素的血清水平。在221名男性的尿液中也检测到DEHP的两种氧化尿液代谢物。在校正潜在混杂因素的多元回归模型中，MEHP与睾酮、雌二醇和游离雄激素指数（FAI）呈负相关。相对于人群中位激素水平，MEHP的四分位距增加分别与睾酮和雌二醇下降4%（95%CI-7%至-1%）和7%（95%CI-11%至-2%）相关。通过尿液中DEHP代谢物的比例（测量为MEHP（MEHP%））对MEHP和FAI之间的负相关性进行影响修饰的证据有限，MEHP被认为是DEHP代谢为其氧化代谢物的效率较低的表型标志物。最后，睾酮与雌二醇的比值与MEHP（p值=0.07）和MEHP%（p值=0.007）呈正相关，表明与芳香化酶抑制的潜在关系。总之，这些结果表明，DEHP的尿液代谢物与成年男性的循环类固醇激素水平呈负相关。然而，需要更多的研究来证实这些发现。
Experimental animal studies have demonstrated that exposure to some phthalates may be associated with altered endocrine function and adverse effects on male reproductive development and function, but human studies are limited. In the present study, urine and serum samples were collected from 425 men recruited through a US infertility clinic. Urinary concentrations of mono(2-ethylhexyl) phthalate (MEHP), the hydrolytic metabolite of di(2-ethylhexyl) phthalate (DEHP), and other phthalate monoester metabolites were measured, along with serum levels of testosterone, estradiol, SHBG, FSH, LH, inhibin B and prolactin. Two oxidized urinary metabolites of DEHP were also measured in urine from 221 of the men. In multiple regression models adjusted for potential confounders, MEHP was inversely associated with testosterone, estradiol, and free androgen index (FAI). An interquartile range increase in MEHP was associated with 4% (95%CI −7% to −1%) and 7% (95%CI −11% to −2%) declines in testosterone and estradiol, respectively, relative to the population median hormone levels. There was limited evidence for effect modification of the inverse association between MEHP and FAI by the proportion of DEHP metabolites in the urine measured as MEHP (MEHP%), which is considered a phenotypic marker of less efficient metabolism of DEHP to its oxidized metabolites. Finally, the ratio of testosterone to estradiol was positively associated with MEHP (p-value=0.07) and MEHP% (p-value=0.007), suggesting potential relationships with aromatase suppression. In conclusion, these results suggest that urinary metabolites of DEHP are inversely associated with circulating steroid hormone levels in adult men. However, additional research is needed to confirm these findings.
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影响因子：
7.4
作者：
Blount, BC;Milgram, KE;Brock, JW
通讯作者：
Brock, JW
影响因子：
10.4
作者：
Hauser R;Meeker JD;Park S;Silva MJ;Calafat AM
通讯作者：
Calafat AM
DOI：
10.1097/00043764-199904000-00010
发表时间：
1999-04-01
影响因子：
3.2
作者：
Fleming, LE;Bean, JA;Hamilton, K
通讯作者：
Hamilton, K
DOI：
10.1016/j.ijheh.2006.09.005
发表时间：
2007-01-01
影响因子：
6
作者：
Fromme, Hermann;Bolte, Gabriele;Liebl, Bernhard
通讯作者：
Liebl, Bernhard
影响因子：
6.1
作者：
Duty, SM;Calafat, AM;Hauser, R
通讯作者：
Hauser, R