Identifying the Need to Discuss Infertility Concerns Affecting Testicular Cancer Patients: An Evaluation (INDICATE Study).
Identifying the Need to Discuss Infertility Concerns Affecting Testicular Cancer Patients: An Evaluation (INDICATE Study).
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DOI：
10.3390/cancers13030553
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发表时间：
2021-02-01
期刊：
影响因子：
5.2
通讯作者：
Elzevier HW
中科院分区：
文献类型：
--
作者：
Krouwel EM;Jansen TG;Nicolai MPJ;Dieben SWM;Luelmo SAC;Putter H;Pelger RCM;Elzevier HW
睾丸癌是年轻男性最常见的恶性肿瘤，影响生育能力。重要的是，在开始治疗之前讨论对生育的影响，以便患者了解风险及其选择。我们研究的目的是评估向睾丸癌男性提供有关生育力影响和精液保存可能性的建议的方式。此外，我们的目的是评估对所提供信息的满意度并确定生殖问题。在 201 名患者的样本中，十分之一的患者表示没有被告知生育力低下的风险。 41.3% 的人进行了精子库，其中 13 名男性使用了保存的精子，为 7 名男性提供了亲子鉴定。在诊断出睾丸癌后，需要立即讨论受试者的生育和精液保存问题，因为如果随后出现生育问题，这会引起护理不满和悲伤。患有睾丸癌 (TC) 的男性存在生育能力受损的风险。由于诊断几乎总是在育龄期且总体生存率较高，因此生育力是 TC 患者的主要关注点。这项研究评估了有关生育能力受损和精子冷冻保存风险的咨询。对 1995 年至 2015 年间诊断的 566 名 TC 患者进行了横断面调查。在 566 名幸存者中，完成了 201 份问卷（35.5%）。 88% 的人被告知生育能力可能受损，9.5% 的人没有被告知。大多数人（47.3%）更愿意由泌尿科医生提供信息。采集精子虽然麻烦，但成功的占25.6%，未成功采集精子的占4.8%。原因是疾病带来的高压、手术后的疼痛以及不舒服的环境。由于生育能力受损，19%的受访者表示悲伤，9.3%的受访者表示对生活不太满意。 41.3% (n = 83) 进行了精子冷冻保存。三分之一（n = 63，31.3%）在治疗后生下了孩子，其中 11.1% 使用保存的精子（n = 7）。这项调查的结果表明了及时与 TC 患者讨论生育问题的重要性。在与大多数男性讨论时，由于生育能力受损和缺乏咨询，可能会出现不满和悲伤。总体而言，6.5% 使用冷冻精子（n = 13）。男性更喜欢泌尿科医生提供生育咨询。
Testicular cancer is the most common malignancy in young males affecting the ability to father children. It’s important that effects on fertility are discussed before starting treatment so patients are aware of the risks and their options. The objective of our study was to evaluate the manner in which men with testicular cancer are counselled about implications on fertility and the possibility of semen preservation. Furthermore, we aimed to evaluate satisfaction with provided information and to identify reproductive concerns. In a sample of 201 patients, one out of ten patients reported not to be informed about the risk of subfertility. Sperm banking was performed by 41.3%, of which 13 men made use of preserved sperm, resulting in paternity for 7 men. The subjects fertility and semen preservation need to be broached promptly after diagnosis of testicular cancer because they cause dissatisfaction with care and grief if fertility problems occur afterwards. Men with testicular cancer (TC) risk impaired fertility. Fertility is a major concern for TC patients due to diagnosis in almost always reproductive ages and high overall survival. This study assessed counselling in regards to the risk of impaired fertility and sperm cryopreservation. A cross-sectional survey was performed on 566 TC patients diagnosed between 1995–2015. Of the 566 survivors, 201 questionnaires were completed (35.5%). Eighty-eight percent was informed about possible impaired fertility, 9.5% was not informed. The majority (47.3%) preferred the urologist to provide information. Collecting sperm was troublesome but successful for 25.6%, 4.8% did not succeed in collecting sperm. The reasons were high pressure due to disease, pain after surgery and uncomfortable setting. Due to impaired fertility, 19% of the respondents reported grief and 9.3% stated as being less satisfied in life. Sperm cryopreservation was performed by 41.3% (n = 83). One third (n = 63, 31.3%) had children after treatment, of which 11.1% made use of preserved sperm (n = 7). The results of this survey indicate the importance of timely discussion of fertility issues with TC patients. While being discussed with most men, dissatisfaction and grief may occur as a result of impaired fertility and a lack of counselling. Overall, 6.5% made use of cryopreserved sperm (n = 13). Men prefer their urologist providing counselling on fertility.
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影响因子：
6.1
作者：
Skakkebæk, NE;Rajpert-De Meyts, E;Main, KM
通讯作者：
Main, KM
影响因子：
12.7
作者：
Guo, Yimeng;Kopec, Jacek A.;Goldsmith, Charles H.
通讯作者：
Goldsmith, Charles H.
影响因子：
3.2
作者：
Bandak, Mikkel;Jorgensen, Niels;Daugaard, Gedske
通讯作者：
Daugaard, Gedske
影响因子：
23.4
作者：
Gurney JK;Florio AA;Znaor A;Ferlay J;Laversanne M;Sarfati D;Bray F;McGlynn KA
通讯作者：
McGlynn KA
影响因子：
1.4
作者：
Garvelink, Mirjam M.;ter Kuile, Moniek M.;Stiggelbout, Anne M.
通讯作者：
Stiggelbout, Anne M.