Early life exposure to green space and insulin resistance: An assessment from infancy to early adolescence.
Early life exposure to green space and insulin resistance: An assessment from infancy to early adolescence.
复制标题
DOI：
10.1016/j.envint.2020.105849
复制
发表时间：
2020-09
影响因子：
11.8
通讯作者：
James P
中科院分区：
文献类型：
--
作者：
Jimenez MP;Oken E;Gold DR;Luttmann-Gibson H;Requia WJ;Rifas-Shiman SL;Gingras V;Hivert MF;Rimm EB;James P
最近的研究表明，更多地接触自然植被或“绿色空间”与降低糖尿病风险有关，可能是通过增加体力活动。但是，关于青年人的绿色空间与胰岛素抵抗的研究有限。我们假设，在生命早期敏感时期，更大的绿色空间与青年胰岛素抵抗较低有关。我们使用的数据来自Project Viva（N=460），这是一项出生前队列研究，招募了1999-2002年马萨诸塞州东部的孕妇，并随访了后代进入青春期。我们定义了婴儿期（中位年龄-1.1岁）、幼儿期（3.2岁）、儿童中期（7.7岁）和青少年早期（12.8岁）的住宅绿色空间暴露，使用30米分辨率的Landsat卫星图像估计归一化植被指数（NDVI）。我们的主要结果是青春期早期估计胰岛素抵抗（HOMA-IR）。我们使用多重插补来解释缺失数据，并使用多重线性回归模型对年龄、性别、种族/民族、父母教育程度、家庭收入和社区家庭收入中位数进行调整。最高的绿色空间三分位数中，白色参与者的比例最高（85%），受过大学教育的母亲（87%）和父亲（85%）以及收入高于7万美元的家庭（86%）。未经调整的模型显示，在婴儿期生活在最高绿色空间三分位数的参与者在青春期早期的HOMA-IR比生活在最低三分位数的参与者低0.15个单位（95% CI：-0.23，-0.06）。然而，在调整后的模型中，我们没有观察到婴儿期至青春期早期的绿色空间与青春期早期的HOMA-IR之间存在关联的证据，尽管一些点估计值在假设的方向上。例如，婴儿期生活在最高绿色空间三分位数的参与者的HOMA-IR比生活在最低三分位数的参与者低0.03个单位（95%CI：-0.14，0.08）。暴露于绿色空间在生命早期敏感的时间段是不相关的HOMA-IR的青年。需要对不同人群的早期生活进行纵向研究，以证实或反驳我们的结果。
Recent studies suggest that greater exposure to natural vegetation, or “green space” is associated with lower diabetes risk, possibly through increasing physical activity. However, there is limited research on green space and insulin resistance in youth. We hypothesized greater green space at early-life sensitive time periods would be associated with lower insulin resistance in youth. We used data from Project Viva (N=460), a pre-birth cohort study that recruited pregnant women in eastern Massachusetts, 1999–2002, and followed offspring into adolescence. We defined residential green space exposure at infancy (median age - 1.1 years), early childhood (3.2 years), mid-childhood (7.7 years), and early adolescence (12.8 years), using 30m resolution Landsat satellite imagery to estimate the Normalized Difference Vegetation Index [NDVI]. Our main outcome was early adolescence estimated insulin resistance (HOMA-IR). We used multiple imputation to account for missing data and multiple linear regression models adjusted for age, sex, race/ethnicity, parental education, household income, and neighborhood median household income. The highest green space tertile had the highest percentage of white participants (85%), college-educated mothers (87%) and fathers (85%), and households with income higher than US$70,000 (86%). Unadjusted models showed that participants living in the highest green space tertile at infancy had a 0.15 unit lower HOMA-IR (95% CI: −0.23, −0.06) in early adolescence, than those living in the lowest tertile. However, in adjusted models, we did not observe evidence of associations between green space from infancy to early adolescence and HOMA-IR in early adolescence, although some point estimates were in the hypothesized direction. For example, participants in the highest green space tertile in infancy had 0.03 units lower HOMA-IR (95%CI: −0.14, 0.08) than those living in the lowest tertile. Exposure to green space at early life sensitive time periods was not associated with HOMA-IR in youth. Early-life longitudinal studies across diverse populations are needed to confirm or refute our results.
登录
查看更多内容
DOI：
10.3390/ijerph110303453
发表时间：
2014-03-21
影响因子：
--
作者：
Beyer KM;Kaltenbach A;Szabo A;Bogar S;Nieto FJ;Malecki KM
通讯作者：
Malecki KM
获得绿色空间，体育锻炼和心理健康：一项双胞胎研究。
影响因子：
6.3
作者：
Cohen-Cline H;Turkheimer E;Duncan GE
通讯作者：
Duncan GE
影响因子：
3.8
作者：
Fleisch AF;Luttmann-Gibson H;Perng W;Rifas-Shiman SL;Coull BA;Kloog I;Koutrakis P;Schwartz JD;Zanobetti A;Mantzoros CS;Gillman MW;Gold DR;Oken E
通讯作者：
Oken E
影响因子：
8.3
作者：
Gascon, Mireia;Sanchez-Benavides, Gonzalo;Nieuwenhuijsen, Mark
通讯作者：
Nieuwenhuijsen, Mark
影响因子：
8.9
作者：
Dadvand, Payam;Poursafa, Parinaz;Kelishadi, Roya
通讯作者：
Kelishadi, Roya