Whole egg consumption and cortical bone in healthy children.
Whole egg consumption and cortical bone in healthy children.
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DOI：
10.1007/s00198-018-4538-1
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Lewis RD
中科院分区：
文献类型：
--
作者：
Coheley LM;Kindler JM;Laing EM;Oshri A;Hill Gallant KM;Warden SJ;Peacock M;Weaver CM;Lewis RD
鸡蛋含有生物活性化合物，被认为有益于儿童骨骼。这项横断面研究表明，儿童时期的鸡蛋摄入量与桡骨皮质骨之间存在正相关关系。如果随机试验证实了我们的发现，将鸡蛋纳入儿童饮食中可能会对预防儿童骨折和降低骨质疏松症风险产生重大影响。这项研究探讨了儿童鸡蛋摄入量与皮质骨之间的关系。横断面研究设计包括 294 名 9-13 岁的黑人和白人男性和女性。三天的饮食记录决定了每天的鸡蛋消耗量。外周定量计算机断层扫描测量桡骨和胫骨皮质骨。分别使用双能 X 射线吸收测定法和 ELISA 评估身体成分和骨转换生物标志物。在未调整的模型中，鸡蛋摄入量与桡骨和胫骨皮质骨矿物质含量（Ct.BMC）、总骨面积、皮质面积、皮质厚度、骨膜周长和极性强度应变指数呈正相关（r = 0.144–0.224，所有 P < 0.050）。在调整种族、性别、成熟度、无脂软组织质量（FFST）和蛋白质摄入量的差异后，胫骨关系无效；然而，鸡蛋摄入量与半径 Ct.BMC 仍呈正相关（r = 0.138，P = 0.031）。仅在未经调整的模型中，鸡蛋摄入量与全身骨矿物质密度、BMC 和骨面积呈正相关（r = 0.119–0.224；所有 P < 0.050）。调整协变量后，在路径分析中，鸡蛋摄入量是半径 FFST 的正预测因子（β = 0.113，P < 0.050），FFST 是 Ct.BMC 的正预测因子（β = 0.556，P < 0.050）。即使在调整中介因素 FFST（β = 0.137，P = 0.020）后，鸡蛋对半径 Ct.BMC 也有直接影响（β = 0.099，P = 0.035）。在未调整（P = 0.005）和调整（P = 0.049）模型中，鸡蛋摄入量与骨钙素呈正相关。如果本研究中观察到的鸡蛋对 Ct.BMC 的积极影响通过未来的随机对照试验得到证实，那么全蛋可能是促进儿童骨骼发育和预防骨折的可行策略。
Eggs contain bioactive compounds thought to benefit pediatric bone. This cross-sectional study shows a positive link between childhood egg intake and radius cortical bone. If randomized trials confirm our findings, incorporating eggs into children’s diets could have a significant impact in preventing childhood fractures and reducing the risk of osteoporosis. This study examined the relationships between egg consumption and cortical bone in children. The cross-sectional study design included 294 9–13-year-old black and white males and females. Three-day diet records determined daily egg consumption. Peripheral quantitative computed tomography measured radius and tibia cortical bone. Body composition and biomarkers of bone turnover were assessed using dual-energy X-ray absorptiometry and ELISA, respectively. Egg intake was positively correlated with radius and tibia cortical bone mineral content (Ct.BMC), total bone area, cortical area, cortical thickness, periosteal circumference, and polar strength strain index in unadjusted models (r = 0.144–0.224, all P < 0.050). After adjusting for differences in race, sex, maturation, fat-free soft tissue mass (FFST), and protein intakes, tibia relationships were nullified; however, egg intake remained positively correlated with radius Ct.BMC (r = 0.138, P = 0.031). Egg intake positively correlated with total body bone mineral density, BMC, and bone area in the unadjusted models only (r = 0.119–0.224; all P < 0.050). After adjusting for covariates, egg intake was a positive predictor of radius FFST (β = 0.113, P < 0.050) and FFST was a positive predictor of Ct.BMC (β = 0.556, P < 0.050) in path analyses. There was a direct influence of egg on radius Ct.BMC (β =0.099, P =0.035), even after adjusting for the mediator, FFST (β = 0.137, P = 0.020). Egg intake was positively correlated with osteocalcin in both the unadjusted (P = 0.005) and adjusted (P = 0.049) models. If the positive influence of eggs on Ct.BMC observed in this study is confirmed through future randomized controlled trials, whole eggs may represent a viable strategy to promote pediatric bone development and prevent fractures.
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DOI：
10.1080/07315724.2002.10719240
发表时间：
2002-10-01
影响因子：
3.5
作者：
Anderson, JJB;Chen, XW;Garner, SC
通讯作者：
Garner, SC
影响因子：
5.8
作者：
Ferira, Ashley J.;Laing, Emma M.;Lewis, Richard D.
通讯作者：
Lewis, Richard D.
影响因子：
4.3
作者：
Agrawal, Manasi;Arora, Shitij;Zaidi, Mone
通讯作者：
Zaidi, Mone
影响因子：
4.1
作者：
Crabtree, NJ;Kibirige, MS;Shaw, NJ
通讯作者：
Shaw, NJ
影响因子：
6.2
作者：
Chevalley, Thierry;Bonjour, Jean-Philippe;Rizzoli, Rene
通讯作者：
Rizzoli, Rene