Partitioning, repressing and derepressing: dynamic regulations in MLA immune receptor triggered defense signaling.

Partitioning, repressing and derepressing: dynamic regulations in MLA immune receptor triggered defense signaling.
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分区、抑制和去抑制:MLA 免疫受体的动态调节触发防御信号

DOI:
10.3389/fpls.2013.00396
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发表时间:
2013-10-08
影响因子:
5.6
通讯作者:
Shen QH
Shen QH
中科院分区:
生物学2区
文献类型:
--
作者:
Chang C;Zhang L;Shen QH

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植物和动物已经进化出细胞内核苷酸结合结构域和富含亮氨酸重复序列的免疫受体(NLR),以感知非自我并触发免疫反应。植物NLR检测菌株特异性病原体效应子并激活免疫信号传导,导致广泛的转录重编程和病原体感染的终止。本文综述了近年来大麦MLA免疫受体介导的抗大麦白粉病免疫反应的研究进展。我们专注于免疫受体的核质分配,免疫信号的分叉,转录抑制和去抑制连接受体激活免疫反应。我们还讨论了类似的发现,从其他植物NLR在适当的情况下。
Plants and animals have evolved intracellular nucleotide-binding domain and leucine-rich repeat-containing immune receptors (NLRs) to perceive non-self and trigger immune responses. Plant NLRs detect strain-specific pathogen effectors and activate immune signaling leading to extensive transcriptional reprogramming and termination of pathogen infection. Here we review the recent findings in barley MLA immune receptor mediated immune responses against the barley powdery mildew fungus. We focus on nucleocytoplasmic partitioning of immune receptor, bifurcation of immune signaling, transcriptional repression and derepression connecting receptor activation to immune responses. We also discuss similar findings from other plant NLRs where appropriate.
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