The Duality of Caspases in Cancer, as Told through the Fly.
The Duality of Caspases in Cancer, as Told through the Fly.
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DOI：
10.3390/ijms22168927
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发表时间：
2021-08-19
影响因子：
5.6
通讯作者：
Fan Y
中科院分区：
文献类型：
--
作者：
Hounsell C;Fan Y
半胱氨酸天冬氨酸蛋白酶是一个半胱氨酸-天冬氨酸蛋白酶家族，在细胞凋亡的激活和启动中起着重要作用。除此之外，已经报道了在增殖、分化、细胞可塑性和细胞迁移中的各种非凋亡半胱天冬酶功能。活性水平和背景是决定caspase功能的重要因素。由于其在细胞凋亡及其他方面的关键作用，半胱天冬酶独特地具有病理作用，包括在癌症中。改变的半胱天冬酶功能是多种癌症中的共同特征，其中凋亡逃避被定义为"癌症的标志"。然而，半胱天冬酶在癌症中发挥的作用要复杂得多，既能预防又能促进肿瘤发生。本文综述了在果蝇中发现的caspase在肿瘤发生中的双重作用。这对癌症治疗有重要意义，包括化疗和放疗，最终目标是激活细胞凋亡。然而，这种治疗可能无意中对促进肿瘤进展和使癌症恶化产生不利影响。全面了解胱天蛋白酶的双重作用将有助于开发成功的癌症治疗方法。
Caspases, a family of cysteine-aspartic proteases, have an established role as critical components in the activation and initiation of apoptosis. Alongside this a variety of non-apoptotic caspase functions in proliferation, differentiation, cellular plasticity and cell migration have been reported. The activity level and context are important factors in determining caspase function. As a consequence of their critical role in apoptosis and beyond, caspases are uniquely situated to have pathological roles, including in cancer. Altered caspase function is a common trait in a variety of cancers, with apoptotic evasion defined as a “hallmark of cancer”. However, the role that caspases play in cancer is much more complex, acting both to prevent and to promote tumourigenesis. This review focuses on the major findings in Drosophila on the dual role of caspases in tumourigenesis. This has major implications for cancer treatments, including chemotherapy and radiotherapy, with the activation of apoptosis being the end goal. However, such treatments may inadvertently have adverse effects on promoting tumour progression and acerbating the cancer. A comprehensive understanding of the dual role of caspases will aid in the development of successful cancer therapeutic approaches.
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DOI：
10.1038/s41576-020-0262-8
发表时间：
2020-11
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
Baker NE
通讯作者：
Baker NE
影响因子：
12.4
作者：
Bell RAV;Megeney LA
通讯作者：
Megeney LA
影响因子：
4.3
作者：
Costa-Rodrigues C;Couceiro J;Moreno E
通讯作者：
Moreno E
DOI：
10.1073/pnas.1113882109
发表时间：
2012-01-10
影响因子：
11.1
作者：
Chen, Chiao-Lin;Schroeder, Molly C.;Halder, Georg
通讯作者：
Halder, Georg
影响因子：
7.3
作者：
Baena-Lopez LA;Arthurton L;Xu DC;Galasso A
通讯作者：
Galasso A