Is Antimicrobial Photodynamic Therapy Effective as an Adjunct to Scaling and Root Planing in Patients with Chronic Periodontitis? A Systematic Review.
Is Antimicrobial Photodynamic Therapy Effective as an Adjunct to Scaling and Root Planing in Patients with Chronic Periodontitis? A Systematic Review.
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DOI：
10.3390/biom7040079
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发表时间：
2017-11-24
期刊：
影响因子：
5.5
通讯作者：
Anil S
中科院分区：
文献类型：
--
作者：
Joseph B;Janam P;Narayanan S;Anil S
本系统评价的目的是调查抗菌光动力疗法 (aPDT) 作为主要治疗方式或非手术治疗的辅助治疗慢性牙周炎在临床附着水平 (CAL) 增益和探诊深度 (PD) 减少方面是否比单独洁治和根面平整 (SRP) 更有效。重点问题是使用患者、干预、比较和结果 (PICO) 格式提出的，两位作者独立检索了 Medline、EMBASE、Cochrane Library、Web of Science、Google Scholar 和 Scopus 数据库以获取 2008 年 1 月至 2016 年 12 月的相关研究。本系统评价中纳入的 20 项研究是 aPDT 与安慰剂、无干预或安慰剂相比的随机临床试验 (RCT) 或准 RCT。成年人群的非手术治疗。研究中收集了基本研究特征、aPDT中使用的光敏剂和波长、aPDT应用频率、aPDT对临床参数的影响、aPDT对慢性牙周炎的抗菌作用、aPDT后免疫学参数的影响以及基于患者的结果测量。尽管纳入的研究存在广泛的异质性，但它们都表明 aPDT 有潜力成为慢性牙周炎治疗的有效辅助手段。在将 aPDT 推荐为有效的治疗方式之前，需要进行更大样本量的长期、多中心研究。
The aim of this systematic review was to investigate whether antimicrobial photodynamic therapy (aPDT) as either a primary mode of treatment or an adjunct to non-surgical treatment was more effective than scaling and root planing (SRP) alone in treating chronic periodontitis in terms of clinical attachment level (CAL) gain and probing depth (PD) reduction. The focused question was developed using the Patient, Intervention, Comparison, and Outcome (PICO) format, and two authors independently searched the Medline, EMBASE, Cochrane Library, Web of Science, Google Scholar, and Scopus databases for relevant studies from January 2008 to December 2016. Twenty studies included in this systematic review were randomized clinical trials (RCTs) or quasi-RCTs of aPDT compared to placebo, no intervention, or non-surgical treatment in an adult population. Basic study characteristics, photosensitizing agents and wavelengths used in aPDT, frequency of aPDT application, effect of aPDT on clinical parameters, antimicrobial effect of aPDT in chronic periodontitis, effect of immunological parameters following aPDT and patient-based outcome measures were collected from the studies. Although there was a wide range of heterogeneity in the included studied, they all indicated that aPDT has the potential to be an effective adjunct in the treatment of chronic periodontitis. Long-term, multicenter studies with larger sample sizes are needed before aPDT can be recommended as an effective treatment modality.
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