Cyclooxgenase-2 inhibiting perfluoropoly (ethylene glycol) ether theranostic nanoemulsions-in vitro study.
Cyclooxgenase-2 inhibiting perfluoropoly (ethylene glycol) ether theranostic nanoemulsions-in vitro study.
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DOI：
10.1371/journal.pone.0055802
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Janjic JM
中科院分区：
文献类型：
--
作者：
Patel SK;Zhang Y;Pollock JA;Janjic JM
Cylcooxgenase-2 (COX-2) expressing macrophages, constituting a major portion of tumor mass, are involved in several pro-tumorigenic mechanisms. In addition, macrophages are actively recruited by the tumor and represent a viable target for anticancer therapy. COX-2 specific inhibitor, celecoxib, apart from its anticancer properties was shown to switch macrophage phenotype from tumor promoting to tumor suppressing. Celecoxib has low aqueous solubility, which may limit its tumor inhibiting effect. As opposed to oral administration, we propose that maximum anticancer effect may be achieved by nanoemulsion mediated intravenous delivery. Here we report multifunctional celecoxib nanoemulsions that can be imaged by both near-infrared fluorescence (NIRF) and 19F magnetic resonance. Celecoxib loaded nanoemulsions showed a dose dependent uptake in mouse macrophages as measured by 19F NMR and NIRF signal intensities of labeled cells. Dramatic inhibition of intracellular COX-2 enzyme was observed in activated macrophages upon nanoemulsion uptake. COX-2 enzyme inhibition was statistically equivalent between free drug and drug loaded nanoemulsion. However, nanoemulsion mediated drug delivery may be advantageous, helping to avoid systemic exposure to celecoxib and related side effects. Dual molecular imaging signatures of the presented nanoemulsions allow for future in vivo monitoring of the labeled macrophages and may help in examining the role of macrophage COX-2 inhibition in inflammation-cancer interactions. These features strongly support the future use of the presented nanoemulsions as anti-COX-2 theranostic nanomedicine with possible anticancer applications.
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用于MRI细胞跟踪的含氟纳米乳液。
DOI：
10.1002/wnan.35
发表时间：
2009-09
影响因子：
8.6
作者：
Janjic, Jelena M.;Ahrens, Eric T.
通讯作者：
Ahrens, Eric T.
影响因子：
3.7
作者：
Hertlein T;Sturm V;Kircher S;Basse-Lüsebrink T;Haddad D;Ohlsen K;Jakob P
通讯作者：
Jakob P
影响因子：
14
作者：
Kaneda, Megan M.;Sasaki, Yo;Lanza, Gregory M.;Milbrandt, Jeffrey;Wickline, Samuel A.
通讯作者：
Wickline, Samuel A.
影响因子：
15
作者：
Janjic, Jelena M.;Srinivas, Mangala;Ahrens, Eric T.
通讯作者：
Ahrens, Eric T.
影响因子：
--
作者：
Krafft, Marie Pierre;Riess, Jean G.
通讯作者：
Riess, Jean G.