The use of microfiber composites of elastin-like protein matrix reinforced with synthetic collagen in the design of vascular grafts.
The use of microfiber composites of elastin-like protein matrix reinforced with synthetic collagen in the design of vascular grafts.
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DOI：
10.1016/j.biomaterials.2010.05.014
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发表时间：
2010-09
期刊：
影响因子：
14
通讯作者：
Chaikof, Elliot L.
中科院分区：
文献类型：
--
作者：
Caves, Jeffrey M.;Kumar, Vivek A.;Martinez, Adam W.;Kim, Jeong;Ripberger, Carrie M.;Haller, Carolyn A.;Chaikof, Elliot L.
关键词：
胶原蛋白和弹性蛋白网络在许多组织和物种中促进高度特化的生物力学反应。生物力学特性，如模量、弹性和强度，最终会影响组织功能和耐久性，以及局部细胞行为。在血管旁路移植的情况下，由于吻合口内膜增生减少，生理压力下的依从性与增加的通畅相关。在本报告中，我们结合细胞外基质（ECM）蛋白类似物制备了由合成胶原微纤维增强的重组弹性蛋白样蛋白基质组成的多层血管移植物。结构分析表明，该制造方案允许纤维取向和体积分数的范围，导致可调的机械性能。破裂强度为239 ~ 2760 mm Hg，顺应性为2.8 ~ 8.4%/100 mm Hg，缝线保持强度为35 ~ 192 gf。最接近所有目标标准的设计显示，破裂强度为1483±43 mm Hg，顺应性为5.1±0.8%/100 mm Hg，缝合保持强度为173±4gf。这些结果表明，通过加入增强性胶原微纤维，重组弹性蛋白基生物材料可以在承载组织替代品中发挥重要作用。我们相信类似的复合材料可以被纳入组织工程方案，在体内植入之前或之后，寻求在结构内整合细胞。
Collagen and elastin networks contribute to highly specialized biomechanical responses in numerous tissues and species. Biomechanical properties such as modulus, elasticity, and strength ultimately affect tissue function and durability, as well as local cellular behavior. In the case of vascular bypass grafts, compliance at physiologic pressures is correlated with increased patency due to a reduction in anastomotic intimal hyerplasia. In this report, we combine extracellular matrix (ECM) protein analogues to yield multilamellar vascular grafts comprised of a recombinant elastin-like protein matrix reinforced with synthetic collagen microfibers. Structural analysis revealed that the fabrication scheme permits a range of fiber orientations and volume fractions, leading to tunable mechanical properties. Burst strengths of 239–2760 mm Hg, compliances of 2.8–8.4%/100 mm Hg, and suture retention strengths of 35–192 gf were observed. The design most closely approximating all target criteria displayed a burst strength of 1483 ± 43 mm Hg, a compliance of 5.1 ± 0.8%/100 mm Hg, and a suture retention strength of 173 ± 4 gf. These results indicate that through incorporation of reinforcing collagen microfibers, recombinant elastomeric protein-based biomaterials can play a significant role in load bearing tissue substitutes. We believe that similar composites can be incorporated into tissue engineering schemes that seek to integrate cells within the structure, prior to or after implantation in vivo.
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影响因子：
4.8
作者：
L'Heureux, N;Pâquet, S;Auger, FA
通讯作者：
Auger, FA
影响因子：
4.9
作者：
Li, Mengyan;Mondrinos, Mark J.;Lelkes, Peter I.
通讯作者：
Lelkes, Peter I.
DOI：
10.1002/jbm.820170203
发表时间：
1983-01-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
LEIDNER, J;WONG, EWC;WILSON, GJ
通讯作者：
WILSON, GJ
影响因子：
4.3
作者：
BASSIOUNY, HS;WHITE, S;ZARINS, CK
通讯作者：
ZARINS, CK
影响因子：
--
作者：
Gui L;Muto A;Chan SA;Breuer CK;Niklason LE
通讯作者：
Niklason LE