Investigation of brain structure in the 1-month infant.
Investigation of brain structure in the 1-month infant.
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DOI：
10.1007/s00429-017-1600-2
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发表时间：
2018-05
影响因子：
3.1
通讯作者：
Davidson RJ
中科院分区：
文献类型：
--
作者：
Dean DC 3rd;Planalp EM;Wooten W;Schmidt CK;Kecskemeti SR;Frye C;Schmidt NL;Goldsmith HH;Alexander AL;Davidson RJ
发育中的大脑经历系统的变化，这些变化发生在成熟的连续阶段。偏离典型的神经发育轨迹被认为是许多儿童早期障碍的基础；因此，表征正常大脑发育的最早模式是至关重要的。最近的神经成像研究提供了对儿童后期和青春期大脑结构的洞察；然而，很少有研究研究婴儿的大脑，特别是3个月以下的婴儿。使用高分辨率结构磁共振成像，我们测量了一个月婴儿(N=143)的皮质下灰质和白质脑体积，并在整个神经发育的早期阶段检查了这些体积测量的特征。我们发现，在生命的第一个月，大脑体积经历了与年龄相关的变化，并有相应的区域不对称和性别二形性模式。具体地说，男性的总脑体积更大，在对总脑体积进行校正后，区域特定脑区的体积因性别而有所不同。与对儿童和青春期后期的研究结果一致，皮质下区域似乎更向右不对称。性别差异和区域不对称都不会随着妊娠校正年龄的变化而改变。我们的结果补充了越来越多的研究与发育相关的最早神经生物学变化的工作，并表明出生时存在不对称和性二型性。
The developing brain undergoes systematic changes that occur at successive stages of maturation. Deviations from the typical neurodevelopmental trajectory are hypothesized to underlie many early childhood disorders; thus, characterizing the earliest patterns of normative brain development is essential. Recent neuroimaging research provides insight into brain structure during late childhood and adolescence; however, few studies have examined the infant brain, particularly in infants under 3 months of age. Using high-resolution structural MRI, we measured subcortical gray and white matter brain volumes in a cohort (N=143) of one-month infants and examined characteristics of these volumetric measures throughout this early period of neurodevelopment. We show that brain volumes undergo age-related changes during the first month of life, with corresponding patterns of regional asymmetry and sexual dimorphism. Specifically, males have larger total brain volume and volumes differ by sex in regionally specific brain regions, after correcting for total brain volume. Consistent with findings from studies of later childhood and adolescence, subcortical regions appear more rightward asymmetric. Neither sex differences nor regional asymmetries changed with gestation-corrected age. Our results complement a growing body of work investigating the earliest neurobiological changes associated with development and suggest that asymmetry and sexual dimorphism are present at birth.
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影响因子：
5.7
作者：
Croteau-Chonka, Elise C.;Dean, Douglas C., III;Deoni, Sean C. L.
通讯作者：
Deoni, Sean C. L.
影响因子：
2.3
作者：
Dean, Douglas C., III;Dirks, Holly;O'Muircheartaigh, Jonathan;Walker, Lindsay;Jerskey, Beth A.;Lehman, Katie;Han, Michelle;Waskiewicz, Nicole;Deoni, Sean C. L.
通讯作者：
Deoni, Sean C. L.
影响因子：
10.6
作者：
Davidson, RJ
通讯作者：
Davidson, RJ
影响因子：
5.7
作者：
Dean DC 3rd;O'Muircheartaigh J;Dirks H;Waskiewicz N;Lehman K;Walker L;Han M;Deoni SC
通讯作者：
Deoni SC
影响因子：
3.1
作者：
Dean DC 3rd;O'Muircheartaigh J;Dirks H;Waskiewicz N;Walker L;Doernberg E;Piryatinsky I;Deoni SC
通讯作者：
Deoni SC