Bacterial communities in neonatal feces are similar to mothers' placentae.
Bacterial communities in neonatal feces are similar to mothers' placentae.
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DOI：
10.1155/2015/737294
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发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Liu CJ
中科院分区：
文献类型：
--
作者：
Dong XD;Li XR;Luan JJ;Liu XF;Peng J;Luo YY;Liu CJ
众所周知，肠道微生物区系对健康有相当大的影响；包括双歧杆菌和乳杆菌在内的某些类型的生物被认为是“良好”的定植细菌，而其他物种则具有潜在的致病性。新生儿最初被殖民会影响他/她今后的健康。最近，研究表明，胎儿在怀孕期间实际上可能会被细菌定植。因此，这项研究是为了评估在婴儿第一次粪便中检测到的细菌种类与从母亲胎盘和阴道获得的样本的相似性。肠道微生物区系在人类健康中起着重要作用。了解新生儿肠道微生物区系的组成是至关重要的。目的了解新生儿第一次粪便微生物群落的性质，并与母亲的胎盘和阴道进行比较。一名通过剖腹产分娩的婴儿与一名经阴道分娩的婴儿进行了比较。利用16S核糖体RNA基因条码火焰法测序，研究细菌群落的组成和每个位点的结构。这两个婴儿的新生儿粪便具有相似的细菌群落，无论采用何种分娩方式，它们都与母亲的胎盘相似。两位母亲的阴道细菌群落不同，但阴道内的不同部位没有不同。与阴道相比，新生儿粪便和母亲胎盘中的细菌显示出相当高的多样性。阴道标本以乳杆菌科为主，粪便和胎盘标本中以微球菌科最多。这些结果可能为婴儿肠道微生物形成的研究提供新的方向。
The gut microbiota is known to have a considerable impact on health; some types of organisms, including bifidobacteria and lactobacilli, are considered to be ‘good’ colonizing bacteria, while other species are potentially pathogenic. The initial colonization of a newborn infant affects his/her health in the future. Recently, research has indicated that the fetus may actually be colonized with bacteria during gestation. Accordingly, this study was conducted to assess the similarities in the bacterial species detected in the infant’s first feces with samples obtained from the mother’s placenta and vagina. The gut microbiota plays an important role in human health. It is essential to understand how the composition of the gut microbiota in neonates is established. To investigate the nature of the microbial community in the first feces of newborn infants compared with the mothers’ placentae and vaginas. One infant who was delivered via Cesarean section was compared with an infant who was delivered vaginally. Bar-coded pyro-sequencing of 16S ribosomal RNA genes was used to investigate the bacterial community composition and structure of each site. Neonatal feces of both infants had similar bacterial communities, and they were similar to the mother’s placenta regardless of the method of delivery. The vaginal bacterial community differed between the two mothers, but not different sites within the vagina. The bacteria in the neonatal feces and the mothers’ placentae demonstrated considerably higher diversity compared with the vaginas. The family Lactobacillaceae dominated in the vaginal samples, while the most abundant family in the fecal and placental samples was Micrococcineae. These results may provide new directions for the study of infant gut microbial formation.
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细菌性阴道病女性的细菌群落：高分辨率系统发育分析揭示了微生物群与临床标准的关系。
影响因子：
3.7
作者：
Srinivasan S;Hoffman NG;Morgan MT;Matsen FA;Fiedler TL;Hall RW;Ross FJ;McCoy CO;Bumgarner R;Marrazzo JM;Fredricks DN
通讯作者：
Fredricks DN
影响因子：
3.7
作者：
Aagaard K;Riehle K;Ma J;Segata N;Mistretta TA;Coarfa C;Raza S;Rosenbaum S;Van den Veyver I;Milosavljevic A;Gevers D;Huttenhower C;Petrosino J;Versalovic J
通讯作者：
Versalovic J
DOI：
10.1073/pnas.1002601107
发表时间：
2010-06-29
影响因子：
11.1
作者：
Dominguez-Bello, Maria G.;Costello, Elizabeth K.;Knight, Rob
通讯作者：
Knight, Rob
影响因子：
4.4
作者：
Oakley, Brian B.;Fiedler, Tina L.;Fredricks, David N.
通讯作者：
Fredricks, David N.
影响因子：
3.7
作者：
CHAO, A;LEE, SM
通讯作者：
LEE, SM