ChIPOTle: a user-friendly tool for the analysis of ChIP-chip data.
ChIPOTle: a user-friendly tool for the analysis of ChIP-chip data.
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DOI:
10.1186/gb-2005-6-11-r97
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发表时间:
2005
期刊:
影响因子:
12.3
通讯作者:
Lieb JD
中科院分区:
文献类型:
--
作者:
Buck MJ;Nobel AB;Lieb JD
ChIPOTle is a new software tool designed specifically for the analysis of ChIP-chip data. ChIPOTle (Chromatin ImmunoPrecipitation On Tiled arrays) takes advantage of two unique properties of ChIP-chip data: the single-tailed nature of the data, caused by specific enrichment but not specific depletion of genomic fragments; and the predictable enrichment of DNA fragments adjacent to sites of direct protein-DNA interaction. Implemented as a Microsoft Excel macro written in Visual Basic, ChIPOTle uses a sliding window approach that yields improvements in the identification of bona fide sites of protein-DNA interaction.
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影响因子:
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DOI:
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