Core-shell NaGdF(4)@CaCO(3) nanoparticles for enhanced magnetic resonance/ultrasonic dual-modal imaging via tumor acidic micro-enviroment triggering.
Core-shell NaGdF(4)@CaCO(3) nanoparticles for enhanced magnetic resonance/ultrasonic dual-modal imaging via tumor acidic micro-enviroment triggering.
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核壳NaGdF4@CaCO3纳米粒子通过肿瘤酸性微环境触发增强磁共振/超声双模态成像
DOI：
10.1038/s41598-017-05395-w
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发表时间：
2017-07-14
影响因子：
4.6
通讯作者：
Liu J
中科院分区：
文献类型：
--
作者：
Wei Z;Lin X;Wu M;Zhao B;Lin R;Zhang D;Zhang Y;Liu G;Liu X;Liu J
对于癌症诊断来说，最大的挑战仍然存在于探索能够以高的目标与背景信号比精确区分肿瘤组织与其周围健康组织的方法中。本文报道了一种具有肿瘤酸性微环境增强超声和磁共振成像信号的NaGdF4@CaCO3-PEG核壳纳米颗粒。在酸性条件下，CaCO 3壳层将逐渐溶解，这将促进NaGdF 4与外部水环境的相互作用，从而增强水质子弛豫。同时，由CaCO 3溶解产生的CO2气泡将产生用于US检测的强弹性回波。通过TEM可以观察到NaGdF4@CaCO3-PEG的核壳结构，通过STEM可以确定其组成。在体外实验中，NaGdF4@CaCO3-PEG可以激发CO2气泡的产生，增强MRI信号;在体内实验中，NaGdF4@CaCO3-PEG也可以在肿瘤部位表现出良好的磁共振/超声双模态肿瘤成像能力。本文描述的具有pH触发的磁共振/超声双模成像增强的概念验证纳米颗粒可以作为未来开发用于癌症诊断的各种分子成像策略的有用指南。
For cancer diagnosis, a paramount challenge still exists in the exploring of methods that can precisely discriminate tumor tissues from their surrounding healthy tissues with a high target-to-background signal ratio. Here, we report a NaGdF4@CaCO3-PEG core-shell nanoparticle which has the tumor acidic microenvironment enhanced imaging signals of ultrasound and magnetic resonance. Under the acidic conditions, the CaCO3 shell will gradually dissolve which then facilitate the interaction of NaGdF4 with the external aqueous environment to enhance water proton relaxation. Meanwhile, the CO2 bubbles generated by the CaCO3 dissolvement will generate strong elastic echo for US detection. The core-shell structure of NaGdF4@CaCO3-PEG can be observed by TEM, and its composition can be determined by STEM. The acid triggered generation of CO2 bubbles and the enhancement of MRI signal could be demonstrated in vitro, and the excellent dual-modal magnetic resonance/ultrasonic cancer imaging abilities of NaGdF4@CaCO3-PEG could be also proved at the tumor site in vivo. The here described proof-of-concept nanoparticles with pH triggered magnetic resonance/ultrasonic dual-modal imaging enhancement, may serve as a useful guide to develop various molecular imaging strategies for cancer diagnosis in the future.
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影响因子：
4.6
作者：
Liao N;Wu M;Pan F;Lin J;Li Z;Zhang D;Wang Y;Zheng Y;Peng J;Liu X;Liu J
通讯作者：
Liu J
影响因子：
11.5
作者：
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通讯作者：
Gambhir, Sanjiv S.
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影响因子：
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作者：
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通讯作者：
Gao, Jinhao
影响因子：
15
作者：
Chou, Shang-Wei;Shau, Yu-Hong;Chen, Chia-Chun
通讯作者：
Chen, Chia-Chun
影响因子：
29.4
作者：
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通讯作者：
Pu, Kanyi