Modulation of redox status in human lung cell lines by organoselenocompounds: selenazolidines, selenomethionine, and methylseleninic acid.
Modulation of redox status in human lung cell lines by organoselenocompounds: selenazolidines, selenomethionine, and methylseleninic acid.
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DOI：
10.1016/j.tiv.2008.08.003
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发表时间：
2008-10
影响因子：
3.2
通讯作者：
Moos, Philip J.
中科院分区：
文献类型：
--
作者：
Poerschke, Robyn L.;Franklin, Michael R.;Moos, Philip J.
利用含硒化合物的癌症预防策略已经证明降低了癌症死亡率和对某些癌症类型的疗效，但所采用的硒化合物之间存在相当大的细胞效应差异。在A549和BEAS-2B人肺细胞系中研究了常规含硒氨基酸、硒代蛋氨酸、氧化硒糖代谢物、甲基亚硒酸和硒唑烷对细胞活力、氧化还原调节和亚细胞区室破坏的影响的可变性。硒蛋氨酸几乎没有影响，而甲基硒酸增加细胞的巯基和应力的内质网。环己基硒唑烷在腺癌细胞系A549中增加了轻度氧化应激，但在正常但病毒转化的细胞系BEAS-2B中效果减弱。这些数据表明，所有的硒化合物是不平等的，有机硒化合物的形式是一个主要的决定因素，在预期的细胞反应。
Cancer prevention strategies utilizing selenium-containing compounds have demonstrated reduced cancer mortality and efficacy for some cancer types but considerable differences in cellular effects exist among the selenocompounds employed. The variability of the effects on cell viability, redox modulation, and disruption of subcellular compartments by the conventional selenium-containing amino acid, selenomethionine, the oxidized selenosugar metabolite, methylseleninic acid, and selenazolidines was investigated in A549 and BEAS-2B human lung cell lines. Selenomethionine had little effect whereas methylseleninic acid increased cellular thiols and stress in the endoplasmic reticulum. The cyclohexylselenazolidine increased mild oxidative stress in the adenocarcinoma cell line, A549, but the effects were attenuated in the normal, but virally transformed cell line, BEAS-2B. These data demonstrate that all selenocompounds are not equal and that the form of the organic selenocompound is a major determinant in the expected cellular response.
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DOI：
10.1016/s1387-2656(05)11004-7
发表时间：
2005-01-01
期刊：
BIOTECHNOLOGY ANNUAL REVIEW, VOL 11
影响因子：
--
作者：
Berridge, MV;Herst, PM;Tan, AS
通讯作者：
Tan, AS
影响因子：
3.5
作者：
Salvioli, S;Ardizzoni, A;Cossarizza, A
通讯作者：
Cossarizza, A
影响因子：
3.4
作者：
Ogra, Y;Hatano, T;Suzuki, KT
通讯作者：
Suzuki, KT
DOI：
10.1093/jnci/92.21.1753
发表时间：
2000-11-01
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Mark, SD;Qiao, YL;Taylor, PR
通讯作者：
Taylor, PR
DOI：
10.1080/00039896.1991.9937427
发表时间：
1991-01-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
CLARK, LC;CANTOR, KP;ALLAWAY, WH
通讯作者：
ALLAWAY, WH