The effect of diet and cardiovascular risk on ovarian aging in cynomolgus monkeys (Macaca fascicularis).
The effect of diet and cardiovascular risk on ovarian aging in cynomolgus monkeys (Macaca fascicularis).
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DOI：
10.1097/gme.0b013e3181d20cd2
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发表时间：
2010-07
期刊：
影响因子：
--
通讯作者：
Kaplan JR
中科院分区：
文献类型：
--
作者：
Appt SE;Chen H;Goode AK;Hoyer PB;Clarkson TB;Adams MR;Wilson ME;Franke AA;Kaplan JR
探讨膳食蛋白质来源、心血管风险、生殖激素与卵巢衰老的关系。成年雌性食蟹猴（Macaca fascicularis）被随机分配到两种含有饱和脂肪和胆固醇的饮食中，仅根据蛋白质来源不同：1)酪蛋白-乳清蛋白（n = 29）或2)大豆异黄酮蛋白（n = 32）。在基线和治疗32个月后测量心血管风险标志物和生殖激素，此时卵巢被切除，连续切片，每100个切片计数卵巢卵泡。酪蛋白-乳清蛋白喂养的猴子比大豆喂养的猴子有更少的原始、初级和次级卵泡（p <0.05）。酪蛋白饲猴的AMH与所有卵泡类型均显著相关（r′s≥0.66,p′s< 0.001），其中与大豆饲猴的初级卵泡（rsoy=0.47, p=0.005）和次级卵泡（rsoy=0.45, p=0.007）显著相关。其他生殖激素的测量和卵泡数量之间没有明显的联系。酪蛋白-乳清蛋白喂养的猴子有更多的致动脉粥样硬化脂蛋白谱和增加的动脉粥样硬化程度（p< 0.05），但是尽管酪蛋白-乳清蛋白喂养的猴子和大豆喂养的猴子在心血管风险方面存在这些差异，但本研究中测量的单个心血管风险指标都没有解释饮食蛋白质来源和卵泡计数之间的关系（线性回归，所有p< 0.05）。饮食对食蟹猕猴卵泡耗竭率的影响然而，这种影响的机制仍未确定。
To determine the relationships among dietary protein source, cardiovascular risk, reproductive hormones and ovarian aging. Adult female cynomolgus monkeys (Macaca fascicularis) were assigned randomly to one of two diets containing saturated fat and cholesterol, differing only by protein source: 1) casein-lactalbumin (n = 29) or 2) soy protein with isoflavones (n = 32). Cardiovascular risk markers and reproductive hormones were measured at baseline and after 32 months of treatment, at which time the ovaries were removed, serially sectioned, and ovarian follicles counted in every 100th section. Casein-lactalbumin-fed monkeys had fewer primordial, primary, and secondary follicles (all p's <0.05) than did their soy-fed counterparts. AMH was significantly correlated with all follicle types (r's≥0.66, p's< 0.001) for casein-fed monkeys, and was significantly correlated with primary (rsoy=0.47, p=0.005) and secondary (rsoy=0.45, p=0.007) follicles in soy-fed monkeys. No significant associations were seen between any of the other reproductive hormones measured and follicle counts. Casein-lactalbumin-fed monkeys had a more atherogenic lipoprotein profile and increased atherosclerosis extent (p< 0.05), but despite these differences in cardiovascular risk between casein-lactalbumin- and soy-fed monkeys, none of the individual cardiovascular risk markers measured in this study explained the relationship between dietary protein source and follicle counts (linear regression, all p's>0.05). Diet influences the rate of follicular depletion in cynomolgus macaques; however, the mechanism for this effect remains undetermined.
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