Interactive effects of estrogen and serotonin on brain activation during working memory and affective processing in menopausal women.
Interactive effects of estrogen and serotonin on brain activation during working memory and affective processing in menopausal women.
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DOI：
10.1016/j.psyneuen.2011.07.007
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发表时间：
2012-03
影响因子：
3.7
通讯作者：
Loughead, James
中科院分区：
文献类型：
--
作者：
Epperson, C. Neill;Amin, Zenab;Ruparel, Kosha;Gur, Ruben;Loughead, James
关键词：
虽然认知变化和情绪不稳定是更年期妇女报告的常见症状，但雌激素产生下降的程度尚不清楚。一些证据表明，雌激素可能通过调节雌激素能功能对认知和情绪产生影响。为了验证这一假设，我们使用色氨酸耗竭（TD）模式来降低健康绝经期妇女的中枢5-羟色胺水平和雌激素水平。我们研究了雌二醇和5-羟色胺对工作记忆、情绪处理和任务相关脑激活的单独和联合作用。8名健康的主要是早期绝经后妇女进行TD或假耗竭，然后在短期经皮雌二醇75-150 μ g/d给药前后进行功能性磁共振成像（fMRI）。在N-back任务（工作记忆）和情感识别任务（情感处理）的执行过程中，通过TD相互作用对大脑激活进行了雌二醇治疗。在2回条件下，TD衰减激活之前，但不是之后，雌二醇治疗的右，左背外侧前额叶和中额/扣带回。在情绪识别过程中，TD提高了眶额叶皮层和双侧杏仁核的激活，雌二醇治疗减弱了这种影响。这些结果为雌激素能效应直接介导雌激素对工作记忆和情感加工过程中脑激活的影响提供了初步证据。
While cognitive changes and mood instability are frequent symptoms reported by menopausal women, the degree to which the decline in estrogen production is responsible is not yet clear. Several lines of evidence suggest that estrogen may produce its effects on cognition and mood through modulation of serotonergic function. To test this hypothesis, we used the tryptophan depletion (TD) paradigm to lower central serotonin levels and pharmacologically manipulated estrogen levels in healthy menopausal women. We examined the individual and combined effects of estradiol and serotonin on working memory, emotion processing and task-related brain activation. Eight healthy predominantly early postmenopausal women underwent TD or sham depletion followed by functional magnetic resonance imaging (fMRI) both before and after short-term transdermal estradiol 75-150 ug/d administration. There was an estradiol treatment by TD interaction for brain activation during performance on both the N-back Task (working memory) and Emotion Identification Task (affective processing). During the 2-back condition, TD attenuated activation prior to, but not after, estradiol treatment in the right and left dorsal lateral prefrontal and middle frontal/cingulate gyrus. During emotion identification, TD heightened activation in the orbital frontal cortex and bilateral amygdala, and this effect was attenuated by estradiol treatment. These results provide preliminary evidence that serotonergic effects directly mediate the impact of estrogen on brain activation during working memory and affective processing.
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