Factors affecting exhaled nitric oxide measurements: the effect of sex.
Factors affecting exhaled nitric oxide measurements: the effect of sex.
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DOI：
10.1186/1465-9921-8-82
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发表时间：
2007-11-15
影响因子：
5.8
通讯作者：
Sears, Malcolm R.
中科院分区：
文献类型：
--
作者：
Taylor, D. Robin;Mandhane, Piush;Greene, Justina M.;Hancox, Robert J.;Filsell, Sue;McLachlan, Christene R.;Williamson, Avis J.;Cowan, Jan O.;Smith, Andrew D.;Sears, Malcolm R.
呼出的一氧化氮（FENO）测量值被用作嗜酸性粒细胞气道炎症的替代标记物。然而，许多宪法和环境因素影响FENO，使其难以制定参考值。我们的目的是评估影响FENO的因素在一个很好的特点成人人口的相对重要性。数据来自达尼丁多学科健康与发展研究的895名32岁的成员。通过未校正和校正线性回归分析，探讨性别、身高、体重、肺功能指标、吸烟、过敏、哮喘和鼻炎对FENO的影响。性别对FENO的影响具有统计学和临床意义，女性FENO水平约低25%。总体而言，当前吸烟使FENO减少高达50%，但这种影响主要发生在FENO测量当天吸烟的人中。特应性增加FENO 60%。在控制了影响FENO的所有其他显著因素后，FENO的性别相关差异仍然显著（p < 0.001）。即使在调整后，FENO值在男性和女性中也存在显著差异。参考值的推导和临床环境中FENO的解释应按性别分层。其他常见的因素，如目前吸烟和特应性也需要考虑在内。
Exhaled nitric oxide (FENO) measurements are used as a surrogate marker for eosinophilic airway inflammation. However, many constitutional and environmental factors affect FENO, making it difficult to devise reference values. Our aim was to evaluate the relative importance of factors affecting FENO in a well characterised adult population. Data were obtained from 895 members of the Dunedin Multidisciplinary Health and Development Study at age 32. The effects of sex, height, weight, lung function indices, smoking, atopy, asthma and rhinitis on FENO were explored by unadjusted and adjusted linear regression analyses. The effect of sex on FENO was both statistically and clinically significant, with FENO levels approximately 25% less in females. Overall, current smoking reduced FENO up to 50%, but this effect occurred predominantly in those who smoked on the day of the FENO measurement. Atopy increased FENO by 60%. The sex-related differences in FENO remained significant (p < 0.001) after controlling for all other significant factors affecting FENO. Even after adjustment, FENO values are significantly different in males and females. The derivation of reference values and the interpretation of FENO in the clinical setting should be stratified by sex. Other common factors such as current smoking and atopy also require to be taken into account.
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影响因子：
6.1
作者：
Jilma, B;Kastner, J;Eichler, HG
通讯作者：
Eichler, HG
DOI：
10.1164/rccm.200406-710st
发表时间：
2005-04-15
影响因子：
24.7
作者：
American Thoracic Society;European Respiratory Society
通讯作者：
European Respiratory Society
DOI：
10.1164/ajrccm.152.2.7543345
发表时间：
1995-08-01
影响因子：
24.7
作者：
KHARITONOV, SA;ROBBINS, RA;BARNES, PJ
通讯作者：
BARNES, PJ
影响因子：
3.1
作者：
Kissoon, N;Duckworth, LJ;Silkoff, PE
通讯作者：
Silkoff, PE
影响因子：
14.2
作者：
Berlyne, GS;Parameswaran, K;Hargreave, FE
通讯作者：
Hargreave, FE